Dissertations
2011
2011Doctorate
RAW 264.7 makrofaj hücrelerinde nitrik oksit sentezi üzerine L-karnitinin etkisi
Ankara University, Sağlık Bilimleri Enstitüsü, Biyokimya (Dr) (Eczacılık)
Research Areas
Biochemistry
Academic Positions
2022 - Continues
2022 - ContinuesAssociate Professor
Ankara University, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü
2017 - Continues
2017 - ContinuesAssistant Professor
Ankara University, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü
2009 - 2011
2009 - 2011Research Assistant
Ankara University, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü
Courses
Journal articles indexed in SCI, SSCI, and AHCI
2019
2019Isolation and Bioactivities Screening of Turkish Microcosmus vulgaris
Konuklugil B., Sertdemir M., Heydari H., KOÇ A.
TURKISH JOURNAL OF FISHERIES AND AQUATIC SCIENCES
, vol.19, no.8, pp.653-659, 2019 (SCI-Expanded)
2018
2018Expression analysis of Akirin-2, NF kappa B-p65 and beta-catenin proteins in imatinib resistance of chronic myeloid leukemia
Karabay A. Z., Koç A., Özkan T., Hekmatshoar Y., Altınok Güneş B., Sunguroğlu A., et al.
HEMATOLOGY
, vol.23, no.10, pp.765-770, 2018 (SCI-Expanded)
2017
2017Apoptotic Effects of Some Tetrahydronaphthalene Derivatives on K562 Human Chronic Myelogenous Leukemia Cell Line
KOÇ A., ÖZKAN T., Hekmatshoar Y., Gurkan-Alp A. S., AKTAN F., Buyukbingol Z., et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
, vol.17, no.14, pp.1924-1930, 2017 (SCI-Expanded)
2016
2016Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells
KARABAY A. Z., KOÇ A., ÖZKAN T., Hekmatshoar Y., SUNGUROĞLU A., AKTAN F., et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
, vol.17, no.7, 2016 (SCI-Expanded)
2015
2015Inhibitory effects of indole alpha-lipoic acid derivatives on nitric oxide production in LPS/IFN gamma activated RAW 264.7 macrophages
KARABAY A. Z., KOÇ A., Gurkan-Alp A. S., Buyukbingol Z., Buyukbingol E.
CELL BIOCHEMISTRY AND FUNCTION
, vol.33, no.3, pp.121-127, 2015 (SCI-Expanded)
2011
2011Effect of L-carnitine on the synthesis of nitric oxide in RAW 264•7 murine macrophage cell line
Koc A., ÖZKAN T., Karabay A. Z., SUNGUROĞLU A., Aktan F.
CELL BIOCHEMISTRY AND FUNCTION
, no.8, pp.679-685, 2011 (SCI-Expanded)
Articles Published in Other Journals
2020
2020Investigation into Antimicrobial and Antiproliferative Effects of Secondary Metabolites of Lactobacillus saerimneri Novel Isolated from Vaginal Flora.
GÜRPINAR S. S., ERYILMAZ M., KOÇ A., PALABIYIK İ. M., GERÇEKER D.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES , vol.17, no.1, 2020 (ESCI)
2016
2016L-Karnitin ve alfa-lipoik asitin, HCT 116 / ve -/- kolon kanser hücre serilerinin proliferasyonu üzerindeki sinerjetik etkileri
KOÇ A., KARABAY A. Z., ÖZKAN T., BÜYÜKBİNGÖL Z., SUNGUROĞLU A., AKTAN F.
Ankara Sağlık Hizmetleri Dergisi
, vol.15, no.2, pp.1-8, 2016 (Peer-Reviewed Journal)
2012
2012Effects of glucosamine on LPS/IFN-γ induced RAW 264.7 macrophage apoptosis
KARABAY A. Z., KOÇ A., ÖZKAN T., SUNGUROĞLU A., AKTAN F., BÜYÜKBİNGÖL Z.
Ankara Üniversitesi Tıp Fakültesi Mecmuası , vol.65, no.1, pp.11-18, 2012 (Peer-Reviewed Journal)
2011
2011Effect of Taurine on Hydrogen Peroxide Production in Lipopolysaccharide Induced RAW 264.7 Macrophage Cells
KARABAY A. Z., KOÇ A., ÖZKAN T., BÜYÜKBİNGÖL Z., SUNGUROĞLU A., AKTAN F.
FABAD J. Pharm. Sci. , vol.33, pp.187-192, 2011 (Peer-Reviewed Journal)
Papers Presented at Peer-Reviewed Scientific Conferences
2022
2022Determination of the Cytotoxic Effects of Antidepressant Drugs (Amitriptyline, Paroxetine, Sertraline and Trazadone) in Human Lung Fibroblast Cells and Their Effects On the Expressions of Suicide Candidate Genes (GRIK2 and Plscr4).
ÇOBANKAYA H., KOÇ A.
8th international Hippocrates Congress on medical and health sciences, Turkey, 04 March 2022, (Summary Text)
2021
2021Role of exosomal miRNAs in imatinib resistance of chronic myeloid leukemia
KARABAY A. Z., ÖZKAN T., KOÇ A., KARADAĞ GÜREL A., Hekmatshoar Y., SUNGUROĞLU A., et al.
13th International Symposium on Pharmaceutical Sciences, Turkey, 22 June 2021, (Summary Text)
2021
2021Evaluation of the effects of SIRT5 modulators on the apoptosis of K562 cells and and SIRT5 and cytochrome c proteins
KOÇ A., ÖZKAN T.
13th International Symposium on Pharmaceutical Sciences, Turkey, 22 June 2021, (Summary Text)
2021
2021Effect of Poloxamer 407 (Pluronic F-127) on the proliferation of K562 imatinib sensitive and resistance chronic myleogenous cell line
KOÇ A.
2. International Baku Scientific Researchers Conference Baku, Azerbeijan, Odlar Yurdu University, Azerbaijan, 28 April 2021, (Full Text)
2020
2020Effect of Lipoic Acid Taurine Combination on Activated Raw 264.7 Macrophages
KOÇ A., Yaprak A., ÖZKAN T.
3rd International Hippocrates Congress on Medicinal and Health Sciences, Ankara, Turkey, 06 March 2020, (Full Text)
2018
2018Effects of Probucol on K562 chronic myelogenous leukemia cell line
AKTAN F., KOÇ A., BÜYÜKBİNGÖL Z., KARABAY A. Z.
16th Annual World Congress on Insulin Resistance, Diabetes and Cardiovascular Disease (WCIRDC), 29 November - 01 December 2018, (Summary Text)
2018
2018Bazı yeni imidazopiridin türevlerinin sentezi, yapı aydınlatılması ve biyolojik aktivite çalışmaları
KARAASLAN Ç., KOÇ A., KARABAY A. Z., GÖKER A. H.
2. Ulusal Marmara Eczacılık Kongresi, Turkey, 14 - 16 November 2018
2018
2018Comparison of the cytotoxic effects of different solvents on HCT 116, HL-60 AND K562 cell proliferations
KOÇ A., KARABAY A. Z., BÜYÜKBİNGÖL Z., AKTAN F.
12th International Symposium of Pharmaceutical Sciences, 26 - 29 June 2018, (Summary Text)
2018
2018Modulation of ER stress related genes by MSM in HCT-116 colon cancer cells
hekmatshoar y., ÖZKAN T., KARABAY A. Z., KOÇ A., SUNGUROĞLU A.
43rd FEBS Congress, 7 - 12 July 2018, (Summary Text)
2018
2018Synthesis and Anticancer Activity Studies of Some Novel Indole Retinoid Derivatives
Gurkan-Alp A. S., Koç A., Karabay A. Z., Büyükbingöl M. E.
International Symposium on Pharmaceutical Sciences (ISOPS-12), Ankara, Turkey, 26 - 29 June 2018, pp.399, (Summary Text)
2018
2018Effect of secondary metabolites of Lactobacillus species isolated from vaginal cultures on the proliferation of HCT 116 colon cancer cells.
ERYILMAZ M., KOÇ A., GÜRPINAR S. S., PALABIYIK İ. M., GERÇEKER D.
6th Congress of the Microbiologists of Macedonia with International Participation, and FEMS Supported Symposium entitled ”Emerging Infections”, Ohrid, Macedonia, 30 May - 02 June 2018, (Summary Text)
2017
2017Aspirin inhibits bcr-abl and its downstream effectors in chronic myeloid leukemia
KARABAY A. Z., KOÇ A., hekmatshoar y., KARADAĞ A., ÖZKAN T.
VI. Molecular Medicine Congress, 22 - 25 May 2017, vol.2, pp.55, (Summary Text)
2016
2016Retinoid analoglarının kronik miyeloid lösemi k562 hücrelerindeki apoptotik etkileri
Koç A., Karabay A. Z., Özkan T., Gurkan-Alp A. S., Aktan F., Büyükbingöl Z., et al.
23. Ulusal Biyoloji Kongresi, Gaziantep, Turkey, 5 - 09 September 2016, pp.183, (Summary Text)
2016
2016Retinoid Analoglarının Kronik Miyeloid Lösemi K562 Hücrelerindeki Apoptotik Etkileri
KOÇ A., KARABAY A. Z., Özkan T., ALP A. S., AKTAN F., BÜYÜKBİNGÖL Z., et al.
23. Ulusal Biyoloji Kongresi, Gaziantep, Turkey, 5 - 09 September 2016, pp.183, (Summary Text)
2015
2015Effects of indole alpha lipoic acid derivatives on cell viability parameters in K562 leukemia cell line
Karabay A. Z., Koç A., Gurkan-Alp A. S., Büyükbingöl Z., Büyükbingöl M. E.
11th International Symposium on Pharmaceutical Sciences (ISOPS-11), Ankara, Turkey, 9 - 12 June 2015, pp.43, (Summary Text)
2015
2015Effect of microenvironment on imatinib resistance of K562 cells
KARABAY A. Z., KOÇ A., AKTAN F., BÜYÜKBİNGÖL Z.
40th FEBS congress The Biochemical Basis of Life, Germany, 04 July 2015, (Summary Text)
2014
2014Synergetic effects of L-Carnitine and α-lipoic acid on viability of HCT 116 cell line.
AKTAN F., KARABAY A. Z., KOÇ A.
WCIRDC, 20 - 22 November 2014, (Summary Text)
2014
2014Effects of indole α-lipoic acid derivatives on nitric oxide production in LPS/IFN-γ activated RAW 264.7 macrophages.
Karabay A. Z., Koç A., Gurkan A. S., Büyükbingöl Z., Büyükbingöl M. E.
FES/EMBO, Paris, France, 30 August - 04 September 2014, pp.281, (Summary Text)
2013
2013Differences between akirin protein levels in imatinib resistant and sensitive K562 cell lines
KOÇ A., KARABAY A. Z., ÖZKAN T., ALTINOK GÜNEŞ B., BÜYÜKBİNGÖL Z., SUNGUROĞLU A., et al.
Molecular Life Sciences International Symposium of the German Society for Biochemistry and Molecular Biology, 3 - 06 October 2013, (Summary Text)
2013
2013Interaction of NFkB and akirin proteins in imatinib resistant and sensitive K562 cell lines.
KOÇ A., ÖZKAN T., KARABAY A. Z., SUNGUROĞLU A., BÜYÜKBİNGÖL Z., AKTAN F.
Analysis of autophagy regulation: Discussion of recent research and new technologies meeting., 03 October 2013, (Summary Text)
2013
2013Examination of common gene targets for β-catenin and NFkB proteins in imatinib sensitive and resistant K562 cell lines. Analysis of autophagy regulation: Discussion of recent research and new technologies meeting
KARABAY A. Z., KOÇ A., ÖZKAN T., SUNGUROĞLU A., BÜYÜKBİNGÖL Z., AKTAN F.
Analysis of autophagy regulation: Discussion of recent research and new technologies meeting, 03 October 2013, (Summary Text)
2012
2012Effects of methylsulfonylmethane on viability of HCT-116 cell line.
KARABAY A. Z., ÖZKAN T., KOÇ A., SUNGUROĞLU A., BÜYÜKBİNGÖL Z.
22nd IUBMB& 37th FEBS Congress, 4 - 09 September 2012, (Summary Text)
2010
2010Effect of Poloxamer 407 on Nitric Oxide Production and Cell Viability in LPS Induced RAW 264.7 Macrophage Cell Line.
KOÇ A., AKTAN F.
8. Annual World Congress on Insulin Resistance, Diabetes and Cardiovascular Disease, 4 - 06 November 2010, (Summary Text)
2010
2010Effect of wnt3a or lithium chloride preconditioning on nitric oxide production in RAW264.7 macrophages and K562 leukemic cell line.
Karabay A. Z., Özkan T., Koç A., Karadağ A., Altınok Güneş B., Büyükbingöl Z., et al.
35th Congress of the Federation-ofmEuropean-Biochemical-Societies, Gothenburg, Sweden, 26 June - 01 July 2010, pp.147, (Summary Text)
2010
2010NF-kappaB activation and complex control of NOS2 gene promoter in K562 imatinib mesylate resistant CML cell line.
ÖZKAN T., KARADAĞ A., ALTINOK B., KARABAY A. Z., KOÇ A., BOZKURT S., et al.
35th FEBS Congress Molecules of Life, Sweden, 26 June - 01 July 2010, (Summary Text)
2010
2010Effect of L-Carnitine on NF-kB Activity in lipopolysaccharide stimulated RAW 264.7 macrophage cell line.
KOÇ A., ÖZKAN T., KARABAY A. Z., SUNGUROĞLU A., AKTAN F.
35. FEBS Kongresi, 26 June - 01 July 2010, (Summary Text)
2010
2010Effect of wnt3a or lithium chloride preconditioning on nitric oxide production in RAW 264.7 macrophages and K562 leukemic cell line.
KARABAY A. Z., ÖZKAN T., KOÇ A., KARADAĞ A., ALTINOK B., BÜYÜKBİNGÖL Z., et al.
35th FEBS Congress Molecules of Life, 26 June - 01 July 2010, (Summary Text)
2009
2009Wheatgrass extract effects lipid peroxidation levels in human promyelocytic leukemia cell line HL-60
ÖZKAN T., BAKAR F., KARABAY A. Z., KOÇ A., ALTINOK B., KARADAĞ A., et al.
. 34. FEBS Kongresi. Life’s Molecular Interactions., 4 - 09 July 2009, (Summary Text)
2009
2009Effect of methylsulfonylmethane on proliferation and nitric oxide production in LPS activated RAW 264.7 cells.
KARABAY A. Z., KOÇ A., ÖZKAN T., SUNGUROĞLU A., AKTAN F., BÜYÜKBİNGÖL Z.
34th FEBS Congress Life’s Molecular Interactions., 4 - 08 July 2009, (Summary Text)
Books
2021
2021İlaç keşfinde biyokimya
Karabay A. Z., Koç A.
in: İlaç keşfi ve geliştirilmesi, Mehmet Alp, Editor, Akademisyen Yayınevi Kitabevi, Ankara, pp.1-254, 2021
Funded Projects
2024 - 2026
2024 - 2026Orlistat'ın LPS/IFN-ÿ ile Uyarılan RAW 264.7 Makrofaj Hücrelerinde Nitrik Oksit Sentezi Üzerindeki Etkilerinin NF-kB, VEGF, SIRT1, FASN Proteinleri Üzerindeki Etkileri İle Birlikte Değerlendirilmesi
Project Supported by Higher Education Institutions
(Project Abstract)
Koç A.
2023 - 2026
2023 - 2026
Bazı Bitkisel Atıklardan Hareketle Yeşil Sentez Yöntemiyle Nanopartikül Eldesi Karakterizasyonu Antimikrobiyal ve Antikanser Aktivitelerinin Araştırılması
Project Supported by Higher Education Institutions
Palabıyık İ. M. (Executive), Saltan İşcan H. G., Eryılmaz M., Koç A., Karaaslan M., Rızvanoğlu S. S., et al.
2025 - 2025
2025 - 2025Motesanibin A2780 ovaryum kanseri hücre serisinde SIRT1/Nrf2 sinyal yolağı üzerindeki etkilerinin araştırılması
Project Supported by Higher Education Institutions
(Project Abstract)
Koç A.
2024 - 2025
2024 - 2025Antidepresan ilaçların (Trazodon sitalopram ve amitriptilinin)'in koruma ve tedavi protokolüne göre olası antiinflamatuar etkinliklerinin karşılaştırılması
Project Supported by Higher Education Institutions
(Project Abstract)
Koç A.
2022 - 2024
2022 - 2024Bazı Yeni 2- ve/veya 6-Sübstitüe-8-Fenilimidazopirimidin (Pürin) ve İmidazopiridin Türevlerinin Sentezi, Yapı ve Regioisomerizm Aydınlatılması, Antikanser Aktivitelerinin İncelenmesi
Project Supported by Higher Education Institutions
Koç A., Göker A. H. (Executive), Doğanç F., Aydın A. S.
2021 - 2023
2021 - 2023Sitalopram ve Bromokriptinin kombine etkilerinin, Caco-2 insan kolorektal adenokarsinoma hücre serisinde değerlendirilmesi
Project Supported by Higher Education Institutions
Koç A. (Executive)
2020 - 2023
2020 - 2023Antidepresan İlaçlar (Trazodone, Sertraline, Paroxetine, Amitriptyline)'ın, İnsan Akciğer ve Mikroglia Hücre Serilerindeki Olası Toksik Etkilerinin, SIRT1/PGC1α/TFAM Sinyal Yolağı ve İntihar Adayı Genler ile İlişkileri
Project Supported by Higher Education Institutions
Koç A. (Executive)
2019 - 2022
2019 - 20225-fluorourasil’in HCT-116 (p53+/+ ve p53-/-) Kolon Kanseri Hücrelerinin Proliferasyonu Üzerindeki Etki Mekanizmasında, Sirtüin-5, p53 ve FOXO3a Proteinlerinin Rolü
Project Supported by Higher Education Institutions
Koç A. (Executive)
2018 - 2022
2018 - 2022
5-Azasitidin ve Trikostatin A’xxnın Ovaryum Kanseri Hücre Membranlarının Lipid Profili Üzerindeki Etki Mekanizmasında P53 ve Sirtüin 1’xxin Rolü
TUBITAK Project
Gökbulut A., Koç A. (Executive)
2018 - 2019
2018 - 2019Sirtüin 5'in K562 kronik miyeloid lösemi hücrelerinin proliferasyonu üzerindeki etki mekanizması
Project Supported by Higher Education Institutions
KOÇ A. (Executive)
2018 - 2019
2018 - 2019Sirtüin 5’in K562 Kronik Miyeloid Lösemi hücrelerinin proliferasyonu üzerindeki etki mekanizması
Project Supported by Higher Education Institutions
Koç A. (Executive)
2017 - 2018
2017 - 2018Antarktika Canlı Kaynaklarından Elde Edilen Mantarların Sekonder Metabolitleri, Biyoaktiviteleri ve İlaç Potansiyelleri
Project Supported by Other Official Institutions
KOÇ A.
2016 - 2017
2016 - 2017Probukolün K562 kronik miyeloid lösemi hücrelerindeki apoptotik etkileri
Project Supported by Higher Education Institutions
KARABAY A. Z. (Executive), KOÇ A.
2011 - 2013
2011 - 2013Beta-Katenin, Nükleer Faktör Kappa B Ve Akirin Proteinlerinin Birliktelikleri Ve Kronik Myeloid Lösemide Imatinib Direncindeki Rolleri
TUBITAK Project
KARABAY A. Z.
2010 - 2011
2010 - 2011MSM, kondriotin sülfat ve glukozaminin LPS/İnterferon gama ile indüklenmiş RAW 264.7 makrofaj hücre serisinde apoptoz ve iNOS gen metilasyonu üzerine etkileri
TUBITAK Project
Activities in Scientific Journals
2018 - Continues
2018 - ContinuesANKARA UNIVERSITESI ECZACILIK FAKULTESI DERGISI
Committee Member
Roles in Event Organizations
Ekim 2022
Ekim 2022
PHARMANKARA III
Scientific Congress
Sezgin Bayındır Z., Eryılmaz M., KOÇ A.
Ankara, Turkey
Citations
Total Citations (SCOPUS): 167
h-index (SCOPUS): 7
Jury Memberships
July-2021
July 2021