Prof. MERAL TUNÇBİLEK

Publication Network

Published journal articles indexed by SCI, SSCI, and AHCI

Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells

POLAT M. F., Durmaz Şahin I., KUL P., Cetin Atalay R., TUNÇBİLEK M.

Bioorganic and Medicinal Chemistry Letters , vol.106, 2024 (SCI-Expanded)

Exploration of novel 6,8,9-trisubstituted purine analogues: synthesis, in vitro biological evaluation, and their effect on human cancer cells

POLAT M. F., İrem D. Ş., Atalay R., TUNÇBİLEK M.

Turkish Journal of Chemistry , vol.48, no.1, pp.108-115, 2024 (SCI-Expanded)

Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis <i>via</i> inhibiting Src in hepatocellular carcinoma cells

Bilget Guven E., Durmaz Sahin I., Altiparmak D., Servili B., Essiz S., Cetin-Atalay R., et al.

RSC MEDICINAL CHEMISTRY , vol.14, no.12, pp.2658-2676, 2023 (SCI-Expanded)

A Novel 6,8,9-Trisubstituted Purine Analogue Drives Breast Cancer Luminal A Subtype MCF-7 to Apoptosis and Senescence through Hsp70 Inhibition

KUL P., TUNÇBİLEK M., ERGÜL M., Tunoglu E. N. Y., Tutar Y.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY , vol.23, no.5, pp.585-598, 2023 (SCI-Expanded)

Entrectinib: A New Selective Tyrosine Kinase Inhibitor Approved for the Treatment of Pediatric and Adult Patients with NTRK Fusion-positive, Recurrent or Advanced Solid Tumors

Osman H. M., Tuncbilek M.

CURRENT MEDICINAL CHEMISTRY , vol.29, no.15, pp.2602-2616, 2022 (SCI-Expanded)

Highly efficient chemical phosphorylation of 6-(4-phenylpiperazine-1-yl)-9-(beta-D-ribofuranosyl)-9H-purine

Polat M. F., TUNÇBİLEK M.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS , vol.40, no.3, pp.233-241, 2021 (SCI-Expanded) Sustainable Development

Design, Synthesis and In Vitro Cytotoxic Activity of New 6,9-Disubstituted Purine Analogues

Kucukdumlu A., TUNÇBİLEK M., GÜVEN E. B., Atalay R. C.

ACTA CHIMICA SLOVENICA , vol.67, no.1, pp.70-82, 2020 (SCI-Expanded)

Synthesis of novel 6-substituted amino-9-(beta-D-ribofuranosyl)purine analogs and their bioactivities on human epithelial cancer cells

TUNÇBİLEK M., Kucukdumlu A., Guven E. B., Altiparmak D., Cetin-Atalay R.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , vol.28, no.3, pp.235-239, 2018 (SCI-Expanded)

Synthesis of Some Substituted 6-Phenyl Purine Analogues and Their Biological Evaluation as Cytotoxic Agents

Kucukdumlu A., TUNÇBİLEK M., Guven E. B., Atalay R. C.

ACTA CHIMICA SLOVENICA , vol.64, no.3, pp.621-632, 2017 (SCI-Expanded)

New drug combination in colorectal cancer treatment: Trifluridine and tipiracil Kolorektal kanser tedavisinde yeni ılaç kombinasyonu: Trifluridin ve tipirasil

Avci T., TUNÇBİLEK M.

Turkiye Klinikleri Journal of Medical Sciences , vol.37, no.4, pp.191-200, 2017 (SCI-Expanded) Sustainable Development

Synthesis of novel substituted purine derivatives and identification of the cell death mechanism

Demir Z., Guven E. B., ÖZBEY S., KAZAK C., Atalay R. C., TUNÇBİLEK M.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , vol.89, pp.701-720, 2015 (SCI-Expanded)

Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(β-d- ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells

TUNÇBİLEK M., Bilget Guven E., Onder T., Cetin Atalay R.

Journal of Medicinal Chemistry , vol.55, no.7, pp.3058-3065, 2012 (SCI-Expanded)

Synthesis, Antimicrobial and Antioxidant Activities of Some Benzimidazole Derivatives

KUŞ C., KILCIGİL G., TUNÇBİLEK M., ALTANLAR N., Coban T., EKE B., et al.

LETTERS IN DRUG DESIGN & DISCOVERY , vol.6, no.5, pp.374-379, 2009 (SCI-Expanded)

Synthesis and in vitro antimicrobial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA

TUNÇBİLEK M., Kiper T., ALTANLAR N.

European Journal of Medicinal Chemistry , vol.44, no.3, pp.1024-1033, 2009 (SCI-Expanded)

Synthesis and antimicrobial evaluation of some new substituted purine derivatives

TUNÇBİLEK M., ALAGÖZ Z., ALTANLAR N., Karayel A., ÖZBEY S.

BIOORGANIC & MEDICINAL CHEMISTRY , vol.17, no.4, pp.1693-1700, 2009 (SCI-Expanded)

Synthesis and crystal structure of 1-benzyl-2-(4-benzyloxyphenyl)-5,6-dichloro-1H-benzimidazole

KAYNAK F. B., ÖZBEY S., TUNÇBİLEK M., ALP M.

STRUCTURAL CHEMISTRY , vol.19, no.3, pp.477-480, 2008 (SCI-Expanded)

Synthesis of new 3-(substituted phenacyl)-5-[3 '-(4H-4-oxo-1-benzopyran-2-yl)-benzylidene]-2,4-thiazolidinediones and their antimicrobial activity

Tuncbilek M., Altanlar N.

ARCHIV DER PHARMAZIE , vol.339, no.4, pp.213-216, 2006 (SCI-Expanded)

Antioxidant properties of flavone-6(4′)-carboxaldehyde oxime ether derivatives

KILCIGİL G., Coban T., Tuncbilek M., Can-Eke B., Bozdag-Dundar O., Ertan R., et al.

Archives of Pharmacal Research , vol.27, no.6, pp.610-614, 2004 (SCI-Expanded)

Evaluation of the antioxidant effects of some flavonylthiazolidinediones by determining their effects on lipid peroxidation, superoxide anion formation, and 2,2-diphenyl-1-picrylhydrazyl stable free radical

Tuncbilek M., EKE B., KILCIGİL G., Coban T., Iscan M.

Biological and Pharmaceutical Bulletin , vol.27, no.6, pp.912-915, 2004 (SCI-Expanded)

5′-Nor Carbocyclic Ribavirin

Tuncbilek M., Schneller S. W.

Nucleosides, Nucleotides and Nucleic Acids , vol.22, no.11, pp.1995-2001, 2003 (SCI-Expanded) Sustainable Development

9-Deaza-5′-noraristeromycin

Tuncbilek M., Schneller S. W.

Bioorganic and Medicinal Chemistry , vol.11, no.15, pp.3331-3334, 2003 (SCI-Expanded)

Synthesis and antimicrobial activity of flavone-3 '-carboxaldehyde oxime ether derivatives

Bozdag-Dundar O., Tuncbilek M., Altanlar N., Ertan R.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH , vol.53, no.7, pp.522-525, 2003 (SCI-Expanded)

Antioxidant activity of 4-flavonil-1,4-dihydropyridine derivatives

Kruk I., Kladna A., Lichszteld K., Michalska T., Aboul-Enein H. Y., TUNÇBİLEK M., et al.

Biopolymers - Biospectroscopy Section , vol.62, no.3, pp.163-167, 2001 (SCI-Expanded)

Synthesis and antimicrobial activity of some new 2-phenyl-N-substituted carboxamido-1H-benzimidazole derivatives

GÖKER A. H., Tuncbilek M., Suzen S., Kus C., Altanlar N.

ARCHIV DER PHARMAZIE , vol.334, no.5, pp.148-152, 2001 (SCI-Expanded)

Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver

Tuncbilek M., KILCIGİL G., Ertan R., Can-Eke B., Iscan M.

PHARMAZIE , vol.55, no.5, pp.359-361, 2000 (SCI-Expanded)

Penetration of the pulp chamber by carbamide peroxide bleaching agents on teeth restored with a composite resin

Gokay O., Tuncbilek M., Ertan R.

JOURNAL OF ORAL REHABILITATION , vol.27, no.5, pp.428-431, 2000 (SCI-Expanded)

Methyl 1-(4-chlorobenzyl)-2-(4-methylpiperazin-1-yl)-1H-benzimidazole-5-carboxylate hemihydrate

Ozcan S., Kendi E., Tuncbilek M., GÖKER A. H.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS , vol.56, pp.459-460, 2000 (SCI-Expanded)

Penetration of the pulp chamber by bleaching agents in teeth restored with various restorative materials

Gokay O., Yilmaz F., Akin S., Tuncbilek M., Ertan R.

JOURNAL OF ENDODONTICS , vol.26, no.2, pp.92-94, 2000 (SCI-Expanded)

Synthesis of a new dihydropyridine derivative containing a known vasodilator khellin

Kilcigil G., Tuncbilek M., Ertan R., Erol K., Yildirim E.

TURKISH JOURNAL OF CHEMISTRY , vol.24, no.3, pp.255-259, 2000 (SCI-Expanded)

Synthesis and antihistaminic H1 activity of 1,2,5(6)-trisubstituted benzimidazoles

GÖKER A. H., Ayhan-Kilcigil G., TUNÇBİLEK M., KUŞ C., Ertan R., Kendi E., et al.

Heterocycles , vol.51, no.11, pp.2561-2573, 1999 (SCI-Expanded)

Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-[4 '-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-3,5-pyridine dicarboxylate

Tuncbilek M., Ozbey S., Kendi E., Yildirim E., Erol K., Ertan R.

FARMACO , vol.54, no.10, pp.660-665, 1999 (SCI-Expanded)

Synthesis and antimicrobial activity of some new flavonyl oxime ether derivatives

Tuncbilek M., Bozdag O., KILCIGİL G., Altanlar N., Buyukbingol E., Ertan R.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH , vol.49, no.10, pp.853-857, 1999 (SCI-Expanded)

Synthesis and antimicrobial activity of some new benzimidazole carboxylates and carboxamides

KILCIGİL G., Tuncbilek M., Altanlar N., GÖKER A. H.

FARMACO , vol.54, no.8, pp.562-565, 1999 (SCI-Expanded)

Synthesis and antimicrobial evaluation of some 3-(substituted phenacyl)-5-[4 '-(4H-4-oxo-1-benzopyran-2-yl)-benzylidene]-2,4-thiazolidinediones

Tuncbilek M., Altanlar N.

FARMACO , vol.54, no.7, pp.475-478, 1999 (SCI-Expanded)

Synthesis of some 4-[3 ' or 4 '-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-1,4-dihydropyridine derivatives as potential calcium channel antagonists

Tuncbilek M., Ertan R.

PHARMAZIE , vol.54, no.4, pp.255-259, 1999 (SCI-Expanded)

Synthesis and antimicrobial activity of flavone-6-carboxaldehyde oxime ether derivatives

KILCIGİL G., Bozdag O., Tuncbilek M., Altanlar N., Ertan R.

PHARMAZIE , vol.54, no.3, pp.228-229, 1999 (SCI-Expanded)

Studies on the synthesis of some substituted flavonyl thiazolidinedione derivatives, II

Bozdag O., Tuncbilek M., KILCIGİL G., Ertan R.

PHARMAZIE , vol.54, no.2, pp.151-152, 1999 (SCI-Expanded)

Studies on the synthesis of some substituted flavonyl thiazolidinedione derivatives-I

Bozdag O., Kılcıgil G., Tuncbilek M., Ertan R.

TURKISH JOURNAL OF CHEMISTRY , vol.23, no.2, pp.163-169, 1999 (SCI-Expanded)

1-benzyl-2-(2,6-dichloroanilinomethyl)-1H-benzimidazole

Kendi E., Ozbey S., Tuncbilek M., GÖKER A. H.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS , vol.54, pp.854-856, 1998 (SCI-Expanded)

The structure of 1-(p-fluorophenylmethyl)-2-(4-methyl-1-piperazinyl)-1H-benzimidazole hydrogen fumarate

Ozbey S., Kendi E., GÖKER A. H., Tuncbilek M.

JOURNAL OF CHEMICAL CRYSTALLOGRAPHY , vol.28, no.6, pp.461-464, 1998 (SCI-Expanded)

Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity

Göker A. H., Tuncbilek M., Ayhan G., Altanlar N.

FARMACO , vol.53, no.6, pp.415-420, 1998 (SCI-Expanded)

Synthesis and antimicrobial activity of some new anilino benzimidazoles.

Tuncbilek M., Göker A. H., Ertan R., Eryigit R., Kendi E., Altanlar N.

Archiv der Pharmazie , vol.330, no.12, pp.372-6, 1997 (SCI-Expanded)

2'-methyl-3'-nitroflavone

Kendi E., Ozbey S., Tuncbilek M., Ertan R.

CRYSTAL RESEARCH AND TECHNOLOGY , vol.31, no.5, pp.611-615, 1996 (SCI-Expanded)

SYNTHESIS AND INHIBITORY ACTIVITIES ON PLATELET-AGGREGATION OF SOME FLAVONOID ANALOGS

GÖKER A. H., TUNCBILEK M., LEONCINI G., BUZZI E., MAZZEI M., ROLLAND Y., et al.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH , vol.45-1, no.2, pp.150-155, 1995 (SCI-Expanded)

SYNTHESIS AND ANTIAGGREGATOR ACTIVITY OF SOME NEW DERIVATIVES OF 4H-1-BENZOPYRAN-4-ONE

GÖKER A. H., AYHAN G., TUNCBILEK M., ERTAN R., LEONCINI G., GARZOGLIO R., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , vol.30, no.7-8, pp.561-567, 1995 (SCI-Expanded)

THE STRUCTURE OF ETHYL ALLYL 1,4-DIHYDRO-2,6-DIMETHYL-4-[4-(4H-4-OXO-1-BENZOPYRAN-2-YL)PHENYL]-3,5-PYRIDINE DICARBOXYLATE

KENDI E., OZBEY S., TUNCBILEK M., ERTAN R., FUN H., YIP B.

JOURNAL OF CHEMICAL CRYSTALLOGRAPHY , vol.24, no.11, pp.747-751, 1994 (SCI-Expanded)

Articles Published in Other Journals

Hepatit C Tedavisinde Yeni Bir İlaç: Dasabuvir

Gümüş B., TUNÇBİLEK M.

Türk Farmakope Dergisi , vol.1, no.1, pp.89-115, 2017 (Peer-Reviewed Journal) Sustainable Development

Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives - Fifth communication: Flavonyl benzyl substituted 2,4-thiazolidinediones

TUNÇBİLEK M., BOZDAĞ DÜNDAR O., Ayhan-Kilcigil G., Ceylan M., Waheed A., Verspohl E. J., et al.

Farmaco , vol.58, no.1, pp.79-83, 2003 (Scopus)

Refereed Congress / Symposium Publications in Proceedings

YENİ BAZI PÜRİN ANALOĞU BİLEŞİKLERİN SENTEZ, YAPI AYDINLATILMASI VE SİTOTOKSİK AKTİVİTELERİ ÜZERİNDE ÇALIŞMALAR

Kul P., Tunçbilek M., Ergül M., Yenilmez Tunoğlu E. N., Tutar Y.

VI. ULUSAL FARMASÖTİK KİMYA KONGRESİ, İstanbul, Turkey, 26 - 29 August 2022, pp.243-254

MOLNUPIRAVIR: A NEW ANTIVIRAL DRUG FOR COVID-19 TREATMENT

KUL P., TUNÇBİLEK M.

2. INTERNATIONAL MARMARA SCIENTIFIC RESEARCH AND INNOVATION CONGRESS, İstanbul, Turkey, 19 April 2022, pp.63

DESIGN SYNTHESIS AND IN VITRO BIOLOGICAL ACTIVITIES OF NEW 6,8,9-TRISUBSTITUTED PURINE DERIVATIVES AS PROMISING HSPs INHIBITORS

KUL P., TUNÇBİLEK M., ERGÜL M., Yenilmez Tunoğlu E., TUTAR Y.

ISOPS-13, Ankara, Turkey, 22 June 2021, pp.65-66

Novel 6, 9-Disubstituted Purine Analogs as Cytotoxic Agents: Synthesis and Identification of the Cell Death Mechanism

TUNÇBİLEK M., Bilget Guven E., Durmaz I., Altiparmak D., Cetin Atalay R.

XXII International Conference on Organic Synthesis – 22-ICOS, Florence-Italy, 16 - 21 September 2018

Design and Synthesis of Novel 8-Aryl Substituted9-Cyclopentyl Purine Derivatives as PotentialCytotoxic Agents

TUNÇBİLEK M., POLAT M. F., Durmaz I., Cetin Atalay R.

The 20th International Research Conference, Paris, France, 27 - 28 August 2018, vol.20, pp.2081-2083

NEW PURINE AND PYRIMIDINE NUCLEOSIDE ANALOGS: SYNTHESISAND CYTOTOXIC ACTIVITY ON SELECTED HUMAN CANCER CELL LINES

Altiparmak D., TUNÇBİLEK M., Durmaz I., Cetin Atalay R.

12th International Symposium onPharmaceutical Sciences (ISOPS-12), Ankara, Turkey, 26 - 29 June 2018, pp.91-92 Sustainable Development

NOVEL 6-SUBSTITUTED PIPERAZINE AND 9-TETRAHYDROPYRANYL PURINE DERIVATIVES: SYNTHESIS AND CYTOTOXIC ACTIVITY ON SELECTED HUMAN CANCER CELL LINES

Demir Uluoglu Z., TUNÇBİLEK M., Durmaz I., Çetin Atalay R.

2nd International Gazi Pharma Symposium Series (GPSS-2017), Ankara, Turkey, 11 - 13 October 2017 Sustainable Development

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