Synthesis and antimicrobial activity of some new flavonyl oxime ether derivatives

Tuncbilek M., Bozdag O., KILCIGİL G., Altanlar N., Buyukbingol E., Ertan R.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.49, sa.10, ss.853-857, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 10
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1055/s-0031-1300514
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
  • Sayfa Sayıları: ss.853-857
  • Anahtar Kelimeler: flavonyl oxime ethers, antifungal and antimicrobial activity, BETA-LACTAM ANTIBIOTICS, ANTIBACTERIAL ACTIVITY, ANTIVIRAL ACTIVITY, CEPHALOSPORINS, INVITRO
  • Ankara Üniversitesi Adresli: Evet

Özet

The synthesis of a series of 6 compounds related to 2-(4'-formyl-phenyl)-4H-1-benzopyran-4-one O-substituted oxime and the results of a study of their biological activity are reported. The structural assignments of the compounds is based upon various spectral data. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compound F3 exhibited the best antifungal activity compared with ketoconazole and fluconazole.