Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives - Fifth communication: Flavonyl benzyl substituted 2,4-thiazolidinediones

TUNÇBİLEK M., BOZDAĞ DÜNDAR O., Ayhan-Kilcigil G., Ceylan M., Waheed A., Verspohl E. J., ...More

Farmaco, vol.58, no.1, pp.79-83, 2003 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1016/s0014-827x(02)01241-7
  • Journal Name: Farmaco
  • Journal Indexes: Scopus
  • Page Numbers: pp.79-83
  • Keywords: Flavonyl thiazolidinediones, Hypoglycemic activity, Synthesis
  • Ankara University Affiliated: Yes

Abstract

A new series of 3-benzyl(p-substituted benzyl)-5-[3′-(4H-4-oxo-1- benzopyran-2-yl)-benzylidene]-2,4-thiazolidinediones (8a-e) were synthesized. These products were prepared by Knoevenagel reaction from 3′-flavone carboxaldehyde and 3-substituted 2,4-thiazolidinediones. In vitro insulinotropic activity was determined for compounds 6a-e, 7a-e, 8b and 8c. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.