Antioxidant properties of flavone-6(4′)-carboxaldehyde oxime ether derivatives

KILCIGİL G., Coban T., Tuncbilek M., Can-Eke B., Bozdag-Dundar O., Ertan R., ...Daha Fazla

Archives of Pharmacal Research, cilt.27, sa.6, ss.610-614, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1007/bf02980158
  • Dergi Adı: Archives of Pharmacal Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.610-614
  • Anahtar Kelimeler: flavone, oxime ether, lipid peroxidation, superoxide dismutase, DPPH, antioxidant, LIPID PEROXIDE FORMATION, ANTIMICROBIAL ACTIVITY, FREE-RADICALS, GUINEA-PIG, FLAVONOIDS, INHIBITORS, MECHANISMS, OXIDASE, LIVER
  • Ankara Üniversitesi Adresli: Evet

Özet

The in vitro antioxidant properties of some flavone-6(4)-carboxaldehyde oxime ether derivatives (Ia-f, IIa-f) were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels by measuring the formation of 2-thiobarbituric acid reactive substances. The free radical scavenging properties of the compounds were also examined in vitro by determining their capacity to scavenge superoxide anions and interact with the stable free radical 2, 2-diphenyl-1-picrylhydrazyl (DPPH). The most active compounds, IIb (Flavone-4′-carboxaldehyde-O-ethyl oxime) and Id (Flavone-6-carboxaldehyde-O-[2-(1-pyrolidino) ethyl] oxime), caused 98 and 79% inhibition of superoxide anion production and DPPH stable free radical at 10-3 M, respectively.