Education Information
2021 - 2022
2021 - 2022Post Doctorate
University of Alberta, Faculty of Medicine, Pediatrics, Canada
2014 - 2019
2014 - 2019Doctorate
Ankara University, Sağlık Bilimleri Enstitüsü, Farmakoloji (Dr) (Eczacılık), Turkey
2008 - 2013
2008 - 2013Undergraduate
Gazi University, Eczacılık Fakültesi, Eczacılık Pr., Turkey
Research Areas
Pharmacology and Therapeutics
Professional Sciences
Pharmacology
Health Sciences
Academic Titles / Tasks
2014 - Continues
2014 - ContinuesResearch Assistant
Ankara University, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü
Published journal articles indexed by SCI, SSCI, and AHCI
2024
2024Mitochondrial fatty acid oxidation is the major source of cardiac ATP production in heart failure with preserved ejection fraction.
Sun Q., Güven B., Wagg C. S., de Oliveira A. A., Silver H., Zhang L., et al.
Cardiovascular research
, 2024 (SCI-Expanded)
2024
2024Obesity Is a Major Determinant of Impaired Cardiac Energy Metabolism in Heart Failure with Preserved Ejection Fraction.
Güven B., Sun Q., Wagg C. S., Almeida de Oliveira A., Silver H., Persad K. L., et al.
The Journal of pharmacology and experimental therapeutics
, vol.388, no.1, pp.145-155, 2024 (SCI-Expanded)
2023
2023Stimulating cardiac glucose oxidation lessens the severity of heart failure in aged female mice.
Sun Q., Wagg C. S., Güven B., Wei K., de Oliveira A. A., Silver H., et al.
Basic research in cardiology
, 2023 (SCI-Expanded)
2023
2023Past and present of beta arrestins: A new perspective on insulin secretion and effect.
GÜVEN B., Onay-Besikci A.
European journal of pharmacology
, vol.956, pp.175952, 2023 (SCI-Expanded)
2023
2023Combined levothyroxine and testosterone treatment for restoring erectile dysfunction in propylthiouracil-induced hypothyroid rats
Korkmaz F. N., Yilmaz-Oral D., Asker H., Guven B., Turkcan D., Kirlangic Ö. F., et al.
JOURNAL OF SEXUAL MEDICINE
, vol.20, no.6, pp.732-741, 2023 (SCI-Expanded)
2023
2023In Vitro and in Silico Evaluation of Some New 1H-Benzimidazoles Bearing Thiosemicarbazide and Triazole as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
ÇELİK İ., Ayhan-Kilcigil G., GÜVEN B., Kara Z., Onay-Besikci A.
POLYCYCLIC AROMATIC COMPOUNDS
, vol.43, no.1, pp.444-455, 2023 (SCI-Expanded)
2022
2022Pleiotropic vascular effects of ivabradine in streptozotocin-induced diabetes
Kara Z., GÜVEN B., BEŞİKCİ A., YILDIRIM N., ALTUNAY H.
EUROPEAN JOURNAL OF PHARMACOLOGY
, vol.916, 2022 (SCI-Expanded)
2022
2022Synthesis, molecular docking, in silico ADME, and EGFR kinase inhibitor activity studies of some new benzimidazole derivatives bearing thiosemicarbazide, triazole, and thiadiazole
ÇELİK İ., Ayhan-Kilcigil G., Karayel A., GÜVEN B., BEŞİKCİ A.
JOURNAL OF HETEROCYCLIC CHEMISTRY
, vol.59, no.2, pp.371-387, 2022 (SCI-Expanded)
2020
2020Metabolic effects of carvedilol through beta-arrestin proteins: investigations in a streptozotocin-induced diabetes rat model and in C2C12 myoblasts
GÜVEN B., Kara Z., BEŞİKCİ A.
BRITISH JOURNAL OF PHARMACOLOGY
, vol.177, no.24, pp.5580-5594, 2020 (SCI-Expanded)
2019
2019Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors
ÇELİK İ., KILCIGİL G., GÜVEN B., Kara Z., Gurkan-Alp A. S., KARAYEL A., et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
, vol.173, pp.240-249, 2019 (SCI-Expanded)
Articles Published in Other Journals
2017
2017Synthesis and Pharmacologic Evaluation of Some Benzimidazole Acetohydrazide Derivatives as EGFR Inhibitors
Demirel S., KILCIGİL G., Kara Z., GÜVEN B., BEŞİKCİ A.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
, vol.14, no.3, pp.285-289, 2017 (ESCI)
Refereed Congress / Symposium Publications in Proceedings
2023
2023Chronic Effects of Carvedilol on Erectile Dysfunction in STZ-Induced Diabetic Rats
GÜVEN ÇİLOĞLU B., YILMAZ ORAL D., KARA Z., GÜR S., BEŞİKCİ A.
14. Uluslararası Tıp ve Sağlık Bilimleri Araştırmaları Kongresi- UTSAK, Ankara, Turkey, 23 - 24 December 2023
2022
2022The Warburg effect is reduced in matured cardiomyocytes due primarily to a decrease in glycolysis
PERSAD K. L., ANDRE D. J., GÜVEN ÇİLOĞLU B., HOUNCAREN M., ZHANG L., GREENWOOD J., et al.
ISHR 2022, Winnipeg, Canada, 6 - 09 September 2022
2022
2022Ketones promote maturation of proliferating H9c2 cardiomyocytes.
PERSAD K. L., GÜVEN B., HOUNCAREN M., LOPASCHUK G.
Society of Heart and Vascular Metabolism, Seoul, South Korea, 16 October 2022
2022
2022Cardiac glucose oxidation is suppressed in heart failure with preserved ejection fraction
SUN Q., GÜVEN B., WAGG C., OLIVEIRA A. A., SILVER H., ZHANG L., et al.
Society for Heart and Vascular Metabolism, Seoul, South Korea, 16 - 19 October 2022
2022
2022Metabolic Effects of Carvedilol on Control and HFpEF Mouse Heart and Hypertrophied H9c2 Cells: The Potential Contribution of a Biased Agonist Effect
GÜVEN B., QIUYU S., PERSAD K. L., WAGG C., OLIVEIRA A. A., SILVER H., et al.
ECCR 2022, Treviso, Italy, 30 September - 02 October 2022
2022
2022Cardiac glucose oxidation is impaired in heart failure with preserved ejection fraction (HFpEF).
Sun Q., Güven B., Wagg C., Olıveıra A. A., Sılver H., Arana A., et al.
ISHR 2022, Winnipeg, Canada, 06 September 2022
2021
2021Treatment with levothyroxine and testosterone ameliorated erectile dysfunction in a rat model of propylthiouracil-induced hypothyroidism
YILMAZ ORAL D., ASKER H., GÜVEN B., KIRLANGIÇ Ö. F., ÖZTEKİN Ç. V., GÜR S.
22nd Annual Fall Scientific Meeting of SMSNA, United States Of America, 24 October 2021
2022
2022The direct metabolic effects of carvedilol in control mice hearts and hypertrophied H9c2 cells
GÜVEN B., WAGG C. S., PERSAD K. L., SUN Q., ANDRE D. J., BEŞİKCİ A., et al.
Pediatrics Research Day, Edmonton, Canada, 06 April 2022
2022
2022Cardiac Glucose Oxidation Rates are Depressed in Heart Failure with Preserved Ejection Fraction (HFpEF)
SUN Q., GÜVEN B., WAGG C. S., OLIVEIRA A. A., SILVER H., ZHANG L., et al.
Pediatrics Research Day, Edmonton, Canada, 06 April 2022
2021
2021Treatment with levothyroxine and testosterone ameliorated erectile dysfunction in rat model of propylthiouracil-induced hypothyroidism
KORKMAZ F., YILMAZ ORAL D., ASKER H., GÜVEN B., TÜRKCAN D., KIRLANGIÇ Ö. F., et al.
22nd Annual Fall Scientific Meeting of SMSNA, Scottsdale, United States Of America, 21 - 24 October 2021, vol.19, pp.30-31
2021
2021CURCUMIN LOADED SEMISOLID SLN DISPERSIONS: FORMULATION OPTIMIZATION AND IN VIVO EVALUATION
KARGILI ŞEN A., BADILLI F. U., YEĞEN G., GÜVEN B., AKSU N. B., BEŞİKCİ A.
13th International Symposium on Pharmaceutical Sciences (ISOPS-13), Turkey, 22 June 2021
2019
2019Design and Synthesis of Some Oxadiazole Bearing Benzimidazole Derivatives as PotentialEpidermal Growth Factor Receptor (EGFR) Inhibitors
ÇELİK İ., KILCIGİL G., GÜVEN B., BEŞİKCİ A., Kara Z.
ICMBC 2019 : International Conference onMedicinal and Biological Chemistry, Barselona, Spain, 15 - 16 August 2019
2019
2019Metabolic effects of carvedilol through β-arrestin-2: investigations in cells and streptozotocin-diabetic rats
GÜVEN B., KARA Z., BEŞİKCİ A.
17th Annual Meeting of the Society for Heart and Vascular Metabolism (SHVM), 23 - 26 June 2019
2018
2018Presence of HCN Channels in Rat Aorta and Prevention of Endothelial Dysfunction with Their Selective Inhibitor Ivabradine
kara z., GÜVEN B., BEŞİKCİ A.
Pharmacology 2018, Londrina, Brazil, 17 - 19 December 2018
2018
2018Synthesis of Some Thiadiazole/Triazole Linked1H-Benzimidazole Derivatives As Inhibitors of EGFR Tyrosine Kinase
ÇELİK İ., KILCIGİL G., BEŞİKCİ A., kara z., GÜVEN B.
Eczacılık Kongre ve Fuarı, Paris, France, 20 - 21 August 2018
2018
2018THE EFFECT OF CARVEDILOL TREATMENT ON ERECTILE DYSFUNCTION IN STREPTOZOTOCIN INDUCED DIABETIC RATS.
YILMAZ D., GÜVEN B., KARA Z., GÜR S., BEŞİKCİ A.
12th INTERNATIONAL SYMPOSIUM ON PHARMACEUTICAL SCIENCES, Ankara, Turkey, 26 - 29 June 2018
2018
2018THE POSSIBLE BENEFICIAL EFFECT OF IVABRADINE TREATMENT ON ERECTILE TISSUE IN A DIABETIC RAT MODEL
YILMAZ D., KARA Z., GÜVEN B., BEŞİKCİ A., GÜR S.
12th INTERNATIONAL SYMPOSIUM ON PHARMACEUTICAL SCIENCES, Ankara, Turkey, 26 - 29 June 2018
2017
2017SYNTHESIS OF SOME 1H-BENZIMIDAZOLES CONTAINING CYCLOHEXYL SUBSTITUTED THIOSEMICARBAZIDES, TRIAZOLES, THIADIAZOLES AS INHIBITORS OF EGFR TYROSINE KINASE
ÇELİK İ., KILCIGİL G., Kara Z., GÜVEN B., BEŞİKCİ A.
GPSS2017, 11 - 13 October 2017
2016
2016Investigation of the Pleiotropic Vascular Effects of Ivabradine in Control and Diabetic Rats
Kara Z., GÜVEN B., BEŞİKCİ A.
20th Annual Meeting of European Council for Cardiovascular Resarch, ECCR, Verona, Italy, 14 - 16 October 2016
Books & Book Chapters
2023
2023Beta Arrestin
BEŞİKCİ A., GÜVEN B.
in: Kalp Yetersizliği ve Tedavisinde Yeni Hedefler, , Editor, Tükiye Klinikleri, pp.159-161, 2023
2021
2021Herpes Enfeksiyonlarında Kullanılan İlaçlar
GÜVEN B., ARSLAN E., BEŞİKCİ A.
in: Viral Enfeksiyonlarda Güncel Tedavi Yaklaşımları ve İmmünizasyon, Erdinç Meral, Editor, Ortadoğu, Ankara, pp.61-68, 2021
2021
2021C Vitamini, D Vitamini, Çinko: COVID-19 Tedavisinde Mikro Besinlerden Makro Beklenti Gerçekçi mi?
GÜVEN B., Kara Z., BEŞİKCİ A.
in: Türkiye Klinikleri, Birengel Serhat, Balık İsmail, Editor, Ortadoğu, Ankara, pp.53-58, 2021
Supported Projects
2023 - 2026
2023 - 2026Korunmuş Ejeksiyon Fraksiyonlu Kalp Yetmezliği Modelinde İnflamatuar Sinyal Yolaklarının Kalp ve Damarlarda İncelenmesi: Keton Tüketiminin ve GGR109a Reseptörlerinin Etkisi
TUBITAK Project
Güven B. (Executive)
2022 - 2024
2022 - 2024FFAR4 agonisti TUG-891’in hiperglisemik koşullarda H9c2 kardiyomiyoblast hücrelerde gevşeme yolağı bileşenleri üzerine etkisinin incelenmesi
Project Supported by Higher Education Institutions
Güven B.
2021 - 2023
2021 - 2023SARS-CoV-2 Main proteaz (Mpro) inhibitörü yeni benzimidazol türevlerinin in silico tasarım, sentez ve biyolojik aktivite değerlendirilmesi
Project Supported by Higher Education Institutions
Kılcıgil G. (Executive), Beşikci A., Güven Çiloğlu B., Şen H. T., Çelik İ.
2018 - 2019
2018 - 2019