Doç. Dr. AYŞEGÜL DURAK

Yayın Ağı

Makaleler 31

1. Acute GLP-1 Agonism Induces Arrhythmogenic Electrical Activity in Aged Mice Heart Through Impaired Cellular Na+ and Ca2+ Handlings: The Role of CK2 Hyperphosphorylation

OLĞAR Y., DURAK A., TURAN B.

Anatolian Journal of Cardiology , cilt.29, sa.2, ss.83-94, 2025 (SCI-Expanded, Scopus, TRDizin)

2. An increase in intercellular crosstalk and electrotonic coupling between cardiomyocytes and nonmyocytes reshapes the electrical conduction in the metabolic heart characterized by short QT intervals in ECGs.

Billur D., Olgar Y., Durak A., Yozgat A. H., Unay S., Tuncay E., et al.

Cell biochemistry and function , cilt.41, sa.8, ss.1526-1542, 2023 (SCI-Expanded, Scopus)

3. Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts

DURAK A., TURAN B.

Journal of Physiology and Biochemistry , cilt.79, sa.2, ss.297-311, 2023 (SCI-Expanded, Scopus)

4. The effects of cisplatin and jaceosidin on SH-SY5Y neuroblastoma cells: an electron microscopic, molecular and biochemical study

BAYRAM P., AKSAK KARAMEŞE S., oezdemir B., DURAK A., BİLLUR D.

ULTRASTRUCTURAL PATHOLOGY , 2023 (SCI-Expanded, Scopus)

5. Comparisons of pleiotropic effects of SGLT2 inhibition and GLP-1 agonism on cardiac glucose intolerance in heart dysfunction

TURAN B., DURAK A., OLĞAR Y., TUNCAY E.

MOLECULAR AND CELLULAR BIOCHEMISTRY , cilt.477, sa.11, ss.2609-2625, 2022 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

6. STIM1-Orai1 interaction mediated calcium influx activation contributes to cardiac contractility of insulin-resistant rats

DURAK A., OLĞAR Y., Genc K., TUNCAY E., AKAT F., DEĞİRMENCİ S., et al.

BMC CARDIOVASCULAR DISORDERS , cilt.22, sa.1, 2022 (SCI-Expanded, Scopus)

7. Insulin-induced recovery in KCNQ1/KCNE1-current accelerates the ventricular action potential repolarization in insulin-resistant aged-rats via affecting beta(3)-adrenergic receptors

OLĞAR Y., DURAK A., BİTİRİM C. V., TUNCAY E., Turan B.

BIOPHYSICAL JOURNAL , cilt.121, sa.3, ss.87, 2022 (SCI-Expanded, Scopus)

8. Insulin acts as an atypical KCNQ1/KCNE1-current activator and reverses long QT in insulin-resistant aged rats by accelerating the ventricular action potential repolarization through affecting the beta(3)-adrenergic receptor signaling pathway

OLĞAR Y., DURAK A., Bitirim C. V., TUNCAY E., Turan B.

JOURNAL OF CELLULAR PHYSIOLOGY , cilt.237, sa.2, ss.1353-1371, 2022 (SCI-Expanded, Scopus)

9. Glucagon-like peptide-1 receptor agonist treatment of high carbohydrate intake-induced metabolic syndrome provides pleiotropic effects on cardiac dysfunction through alleviations in electrical and intracellular Ca2+ abnormalities and mitochondrial dysfunction

Durak A., Akkuş E., Gökçay Canpolat A., Tuncay E., Çorapçıoğlu D., Turan B.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY , cilt.49, ss.46-59, 2022 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

10. Ticagrelor alleviates high-carbohydrate intake induced altered electrical activity of ventricular cardiomyocytes by regulating sarcoplasmic reticulum-mitochondria miscommunication

OLĞAR Y., DURAK A., Degirmenci S., TUNCAY E., BİLLUR D., ÖZDEMİR S., et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY , cilt.476, sa.10, ss.3827-3844, 2021 (SCI-Expanded, Scopus)

11. Investigation of the Effect of the Antiaggregant Agent Ticagrelor on the Electrical and Mechanical Activities of Rat Heart With Type 1 Diabetes

DURAK A., TUNCAY E., DEĞİRMENCİ S., TURAN B.

Ankara Üniversitesi Tıp Fakültesi Mecmuası , 2021 (TRDizin)

12. The Relationship Between Metabolic Syndrome Development and Tissue Trace Elements Status and Inflammatory Markers

Akdas S., Turan B., DURAK A., ARIBAL AYRAL P., YAZIHAN N.

BIOLOGICAL TRACE ELEMENT RESEARCH , cilt.198, sa.1, ss.16-24, 2020 (SCI-Expanded, Scopus)

13. Titin and CK2 alpha are New Intracellular Targets in Acute Insulin Application-Associated Benefits on Electrophysiological Parameters of Left Ventricular Cardiomyocytes From Insulin-Resistant Metabolic Syndrome Rats

DURAK A., Bitirim C. V., Turan B.

CARDIOVASCULAR DRUGS AND THERAPY , cilt.34, sa.4, ss.487-501, 2020 (SCI-Expanded, Scopus)

14. Ticagrelor reverses the mitochondrial dysfunction through preventing accumulated autophagosomes-dependent apoptosis and ER stress in insulin-resistant H9c2 myocytes

OLĞAR Y., TUNCAY E., BİLLUR D., DURAK A., ÖZDEMİR S., Turan B.

MOLECULAR AND CELLULAR BIOCHEMISTRY , cilt.469, sa.1-2, ss.97-107, 2020 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

15. beta(3)-adrenergic receptor activation plays an important role in the depressed myocardial contractility via both elevated levels of cellular free Zn2+ and reactive nitrogen species

TUNCAY E., OLĞAR Y., DURAK A., Degirmenci S., BİTİRİM C. V., Turan B.

JOURNAL OF CELLULAR PHYSIOLOGY , cilt.234, sa.8, ss.13370-13386, 2019 (SCI-Expanded, Scopus)

16. Zn2+-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes

TUNCAY E., BİTİRİM C. V., OLĞAR Y., DURAK A., Rutter G. A., Turan B.

MITOCHONDRION , cilt.44, ss.41-52, 2019 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

17. A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

DURAK A., OLĞAR Y., Degirmenci S., AKKUŞ E., TUNCAY E., Turan B.

CARDIOVASCULAR DIABETOLOGY , cilt.17, 2018 (SCI-Expanded, Scopus)

18. Aging related functional and structural changes in the heart and aorta: MitoTEMPO improves aged-cardiovascular performance

OLĞAR Y., DEĞİRMENCİ S., DURAK A., BİLLUR D., CAN B., KAYKI MUTLU G., et al.

Experimental Gerontology , cilt.110, ss.172-181, 2018 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

19. An Investigation on Molecular Basis of the Effects of SGLT2 İnhibitor Dapagliflozin on Hyperglycemia-Associated Heart Dysfunction*

DURAK A., OLĞAR Y., DEĞİRMENCİ S., Ertürk N., akbaş M. t., aygün a., et al.

JOURNAL OF CELLULAR PHYSIOLOGY , cilt.71, 2018 (SCI-Expanded, Scopus)

20. Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat

AKAT F., FIÇICILAR H., DURAK A., TUNCAY E., Dursun A. D., TOPAL ÇELİKKAN F., et al.

ANATOLIAN JOURNAL OF CARDIOLOGY , cilt.19, sa.4, ss.259-266, 2018 (SCI-Expanded, Scopus, TRDizin)

21. Increased free Zn2+ correlates induction of sarco(endo)plasmic reticulum stress via altered expression levels of Zn2+-transporters in heart failure

OLĞAR Y., DURAK A., TUNCAY E., BİTİRİM C. V., ÖZÇINAR E., İNAN M. B., et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE , cilt.22, sa.3, ss.1944-1956, 2018 (SCI-Expanded, Scopus)

22. Cytosolic increased labile Zn2+ contributes to arrhythmogenic action potentials in left ventricular cardiomyocytes through protein thiol oxidation and cellular ATP depletion

DEĞİRMENCİ S., OLĞAR Y., DURAK A., TUNCAY E., Turan B.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY , cilt.48, ss.202-212, 2018 (SCI-Expanded, Scopus)

23. Onset of decreased heart work is correlated with increased heart rate and shortened QT interval in high-carbohydrate fed overweight rats

DURAK A., OLĞAR Y., TUNCAY E., Karaomerlioglu I., Mutlu G., ARIOĞLU İNAN E., et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY , cilt.95, sa.11, ss.1335-1342, 2017 (SCI-Expanded, Scopus)

24. Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart

TUNCAY E., BİTİRİM C. V., DURAK A., Carrat G. R. J., Taylor K. M., Rutter G. A., et al.

DIABETES , cilt.66, sa.5, ss.1346-1358, 2017 (SCI-Expanded, Scopus)

25. Both Reactive ROS and RNS Contribute to Intracellular Free Zn2+ Regulation in Cardiomyocytes Via Zinc Transporter ZIP7 Under Hyperglycemia

TUNCAY E., Bitirim V., DURAK A., Rutter G. A., Turan B.

FREE RADICAL BIOLOGY AND MEDICINE , cilt.100, 2016 (SCI-Expanded, Scopus)

26. Interplay Between Cytosolic Free Zn2+ and Mitochondrion Morphological Changes in Rat Ventricular Cardiomyocytes

BİLLUR D., TUNCAY E., Okatan E. N., OLĞAR Y., Durak A., DEĞİRMENCİ S., et al.

BIOLOGICAL TRACE ELEMENT RESEARCH , cilt.174, sa.1, ss.177-188, 2016 (SCI-Expanded, Scopus)

27. Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction

Okatan E. N., Durak A., Turan B.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY , cilt.94, sa.10, ss.1064-1073, 2016 (SCI-Expanded, Scopus)

28. Immuno-spin trapping detection of antioxidant/pro-oxidant properties of zinc or selenium on DNA and protein radical formation via hydrogen peroxide

Deletioglu V., TUNCAY E., Toy A., Atalay M., Turan B.

MOLECULAR AND CELLULAR BIOCHEMISTRY , cilt.409, sa.1-2, ss.23-31, 2015 (SCI-Expanded, Scopus)

29. Pioglitazonun Metabolik Sendromlu Sıçan Kalp Fonksiyonuna Etkisinin Elektrofizyolojik Yöntemlerle İncelenmesi

DURAK A., TUTAR SELÇUK M. F., OLĞAR Y., OKATAN E. N., DEĞİRMENCİ S., aksu s., et al.

Ankara Üniversitesi Tıp Fakültesi Mecmuası , 2015 (TRDizin)

30. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress

ÇİÇEK F., Toy A., TUNCAY E., CAN B., Turan B.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES , cilt.46, sa.5, ss.377-387, 2014 (SCI-Expanded, Scopus)

31. Enhancement of Cellular Antioxidant-Defence Preserves Diastolic Dysfunction via Regulation of Both Diastolic Zn2+ and Ca2+ and Prevention of RyR2-Leak in Hyperglycemic Cardiomyocytes

TUNCAY E., Okatan E. N., Toy A., Turan B.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY , cilt.2014, 2014 (SCI-Expanded, Scopus)

Hakemli Bilimsel Toplantılarda Yayımlanmış Bildiriler 28

1. Insulinotropic therapy in aging: GLP agonism and cardiovascular effects

OLĞAR Y., DURAK A., TURAN B.

4.Uluslararası 33.Ulusal Biyofizik Kongresi, Adıyaman, Türkiye, 31 Ağustos 2022, (Özet Bildiri)

2. DIFFERENTIAL EFFECTS OF GLP-1 RECEPTOR AGONIST APPLICATIONS ON THE REMODELING OF AGING-HEART

DURAK A., OLĞAR Y., TURAN B.

8th European Section Meeting of the International Academy of Cardiovascular Sciences, Szeged, Macaristan, 01 Ekim 2022, (Özet Bildiri)

3. INVESTIGATION OF THE EFFECT OF SOCE ON AGEİNG-RELETAD INTRACELLULAR Ca2+ CHANGES

DURAK A.

8. ULUSLARARASI ERCİYES BİLİMSEL ARAŞTIRMALAR KONGRESİ, Kayseri, Türkiye, 01 Eylül 2022, (Özet Bildiri)

4. INVESTIGATING OF TRPC CHANNELS, THE CONTRIBUTION OF INTRACELLULAR CALCIUM CHANGING IN METABOLIC SYNDROME

DURAK A.

MAS 16 th INTERNATIONAL European Conference On Mathematics, Engineering, Natural & Medical Sciences, Mardin, Türkiye, 22 Şubat 2022, (Özet Bildiri)

5. COMPARISON OF FEMALE AND MALE IN THE FORMATION OF METABOLIC SYNDROME

DURAK A.

2. uluslararası multidisipliner başkent kongresi, Ankara, Türkiye, 24 Şubat 2022, (Özet Bildiri)

6. YAŞLANMADA LIRAGLITUDE’nin KALP FONKSİYONUNA ETKİLERİ

DURAK A.

8TH INTERNATIONAL GEVHER NESİBE HEALTH SCIENCES CONFERENCE NOVEMBER 19-20, 2021 / ISTANBUL, TURKEY, İstanbul, Türkiye, 19 Kasım 2021, (Özet Bildiri)

7. EFFECT Of GLP-1 AGONİST LİRAGLUTİDE ON CARDİAC DYSFUNCTİON CAUSED BY METABOLİC SYNDROME

DURAK A.

4TH INTERNATIONAL HEALTH SCIENCES AND INNOVATION CONGRESS, New York, Amerika Birleşik Devletleri, 05 Temmuz 2021, (Özet Bildiri)

8. INVESTIGATION OF THE EFFECT OF LIRAGLITUDE ON ACTION POTENTIAL AND CHANNEL CURRENTS IN CARDIOMYOCYTES WITH TYPE 2 DIABETES

DURAK A.

II. Uluslararası Bilim ve İnovasyon Kongresi, Türkiye, 25 Haziran 2021, (Özet Bildiri)

9. The Effect Of Soce On The Heart Function Disorder In Metabolic Syndrome

DURAK A., TURAN B.

1. INTERNATIONAL HEALTH SCIENCES, BIOMEDICAL AND INNOVATIVE APPROACH CONGRESS 21-22 May 2021/ Ankara, Ankara, Türkiye, 21 Mayıs 2021, (Özet Bildiri)

10. Insulin Similar to Activator of KCNQ1 Channel Recovers the Prolonged Repolarization of Ventricular Cardiomyocytes from Insulin Resistant Aged Rats

Turan B., OLĞAR Y., DURAK A., TUNCAY E.

Annual Meeting on Experimental Biology, California, Amerika Birleşik Devletleri, 4 - 07 Nisan 2020, cilt.34, (Özet Bildiri)

11. İnsülin Uygulamasının Oksidatif Stresİndüklü Kalp Fonksiyon Bozukluğundaki Koruyucu Etki Yolağının Metebolik Sendromlu Sıçan Ventrikül Kardiyomiyositlerinde İncelenmesi

DURAK A., BİTİRİM C. V., TURAN B.

31. ulusal biyofizik kongresi, Adana, Türkiye, 09 Ekim 2019, (Özet Bildiri)

12. Mitochondria-targeted antioxidants in aging related functional changes in the heart and aorta: MitoTEMPO improves aged-cardiovascular performance

OLĞAR Y., DEĞİRMENCİ S., DURAK A., TURAN B.

Minutes of the 13th Conference on Mitochondrial Physiology The role of mitochondria in health, disease and drug discovery- COST MitoEAGLE perspectives MIP2018 and MitoEAGLE WG and MC Meeting, Jurmala, Letonya, 20 Eylül 2018, (Özet Bildiri)

13. REGULATION OF MITOCHONDRIAL ZN2 LEVEL BY ZN2 TRANSPORTER ZIP7 EFFECTS SARCO(ENDO)PLASMIC RETICULUM S(E)R-MITOCHONDRIA COUPLING IN HYPERGLYCEMIA

TUNCAY E., BİTİRİM C. V., OLĞAR Y., TOY A., TURAN B.

13 th Conference on Mitochondirial Physiology MİP2018/ MitoEAGLE, Jurmala, Letonya, 18 - 21 Eylül 2018, (Tam Metin Bildiri)

14. High-Carbohydrate Diet-Induced Insulin Resistance Causes Apoptosis at Rats’ Cortical Neurons

KIZIL Ş., BAYRAM P., NAKKAŞ H., BİLLUR D., TOY A., OLĞAR Y., et al.

1st International Food and Medicine Congress, 24 - 27 Mayıs 2018, (Özet Bildiri)

15. The High Sucrose Diet Affects Memory and Learning

BAYRAM P., BİLLUR D., KIZIL Ş., ÇALIŞKAN H., CAN B., TOY A., et al.

1st International Food and Medicine Congress, 24 - 27 Mayıs 2018, (Özet Bildiri)

16. beta 3-Adrenergic Receptor Regulation of Cardiac Ion Channels in Overweight Insulin Resistant Rats

DURAK A., OLĞAR Y., TUNCAY E., Turan B.

62nd Annual Meeting of the Biophysical-Society, San-Francisco, Kostarika, 17 - 21 Şubat 2018, cilt.114, (Özet Bildiri)

17. Cardioprotective action of intermittent hypoxia on left ventricle function in type 1 diabetic rats

AKAT F., FIÇICILAR H., BAŞTUĞ M., TOY A., TURAN B., SABUNCUOĞLU B., et al.

FEPS 2017, 13 - 15 Eylül 2017, (Özet Bildiri) Sürdürülebilir Kalkınma

18. Cardioprotective Action of Intermittent Hypoxia on Left Ventricle Function of Type 1 Diabetic Rats

AKAT F., FIÇICILAR H., BAŞTUĞ M., TUNCAY E., DURAK A., DURSUN A. D., et al.

FEPS 2017 Joint Meeting of The Federation of European Physiological Societies and Austrian Physiological Society, Viyana, Avusturya, 13 - 15 Eylül 2017, (Özet Bildiri) Sürdürülebilir Kalkınma

19. Zn - Transporters ZIP7 and ZNT7 Play Important Role n Progresson of Cardac Dysfuncton Va Affectng S(ER)-Mtochondra Couplng n Hyperglycemc Rat Heart

BİTİRİM C. V., DURAK A., TURAN B., TUNCAY E.

International Congress of the Molecular Biology Association of Turkey, İstanbul, Türkiye, 08 Eylül 2017, (Özet Bildiri)

20. Expression levels of zinc transporters in human failing heart

TOY A., BİTİRİM C. V., OLĞAR Y., TURAN B., ÖZÇINAR E., TUNCAY E., et al.

34th Annual Meeting, EuropeanSection of the International Society for Heart Research,July 24–37, 2017, Hamburg, Germany, 24 - 27 Temmuz 2017, (Özet Bildiri)