Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat

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AKAT F., FIÇICILAR H., DURAK A., TUNCAY E., Dursun A. D., TOPAL ÇELİKKAN F., ...Daha Fazla

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.19, sa.4, ss.259-266, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.14744/anatoljcardiol.2018.00236
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.259-266
  • Anahtar Kelimeler: diabetic cardiomyopathy, intermittent hypoxia, hypoxia-inducible factor (HIF), vascular endothelial growth factor ( VEGF), angiogenesis, ENDOTHELIAL GROWTH-FACTOR, INDUCIBLE FACTOR-1 HIF-1, CARDIAC DYSFUNCTION, OXIDATIVE STRESS, ISCHEMIA/REPERFUSION INJURY, MATRIX METALLOPROTEINASES, GENE-EXPRESSION, DOWN-REGULATION, CARDIOMYOPATHY, INHIBITION
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Depressed mechanical activity is a marked complication in diabetics. Hypoxia has properties for novel diagnostic and therapeutic strategies, while intermittent hypoxia (IH) provides early functional and histologic remodeling, including some cardio benefits in early hemodynamic alterations with histologic remodeling and delayed changes in peripheral vasoreactivity. Therefore, we aimed to examine whether IH application presents a cardioprotective effect, via stabilization of hypoxia-inducible factor (HIF) in streptozotocin (STZ)-induced diabetic rat heart.