Expression of inhibitor proteins that control primordial follicle reserve decreases in cryopreserved ovaries after autotransplantation

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ÇELİK S., TOPAL ÇELİKKAN F., ÖZKAVUKCU İ. S., CAN A., ÇELİK ÖZENCİ Ç.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.35, sa.4, ss.615-626, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s10815-018-1140-6
  • Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.615-626
  • Anahtar Kelimeler: Ovarian tissue cryopreservation, Primordial follicle, Pten, Tsc1, p27, AMH, ANTI-MULLERIAN HORMONE, FERTILITY PRESERVATION, CANCER-PATIENTS, ACTIVATION, GROWTH, TISSUE, TRANSPLANTATION, HYPOXIA, MICE, P27(KIP1)
  • Ankara Üniversitesi Adresli: Evet

Özet

Even with 86 live births reported globally so far, the mechanism of primordial follicle loss following autotransplantation of the frozen-thawed ovarian tissue needs further evaluation. Pten, Tsc1, p27, and Amh are the inhibitor proteins that play crucial roles in suppressing the transition from the primordial follicle to primary state, maintaining the primordial follicle reserve. In this study, we aimed to evaluate whether the expression patterns of these proteins change and it may be related to the global primordial follicle loss after autotransplantation of the frozen-thawed ovarian tissue.