Synthesis and microbiological activity of 5(or 6)-methyl-2-substituted benzoxazole and benzimidazole derivatives

Oren İ., Temiz O., Yalcin I., Sener E., Akin A., Ucarturk N.

Arzneimittel-Forschung/Drug Research, cilt.47, sa.12, ss.1393-1397, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 12
  • Basım Tarihi: 1997
  • Dergi Adı: Arzneimittel-Forschung/Drug Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1393-1397
  • Anahtar Kelimeler: benzimidazole, microbiological activity, synthesis, benzoxazoles, microbiological activity, synthesis, ANTITUMOR AGENTS, TOPOISOMERASE-II, INHIBITORS, ANALOGS, DNA, OXAZOLO(4,5-B)PYRIDINES, A23187
  • Ankara Üniversitesi Adresli: Evet

Özet

The synthesis and microbiological activity of a new series of 5(or 6)- methyl-2-substituted benzoxazoles (IVa-n) and benzimidazoles (Va-h) were described. The in vitro microbiological activity of the compounds was determined against gram-positive, gram-negative bacteria and the yeast Candida albicans in comparison to reference drugs. Microbiological results indicated that the derivatives possessed a broad spectrum of activity against the tested microorganisms and the compounds IVa-g, IVi-k, IVn, Vb-c and Vh showed significant activity against Pseudomonas aeruginosa having MIC values of 25 μg/ml, providing higher potencies than the reference drugs tetracycline and streptomycin. Moreover, the derivative 5-methyl-2-p- chlorobenzyl)benzoxazole (IVb) possessed the same potency against Candida albicans as the reference drugs oxiconazole and haloprogin having a MIC value of 6.25 mg/ml. However, none of the derivatives showed a better spectrum of activity than the reference drugs.