Interaction of phenoxybenzamine with angiotensin II in the isolated perfused rabbit kidney. Short communication

Ercan Z., Turker R., Bor N., Torunoglu M.

Arzneimittel-Forschung/Drug Research, vol.27, no.10, pp.1996-1997, 1977 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 10
  • Publication Date: 1977
  • Journal Name: Arzneimittel-Forschung/Drug Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, International Pharmaceutical Abstracts
  • Page Numbers: pp.1996-1997
  • Ankara University Affiliated: Yes

Abstract

Interaction of phenoxybenzamine with angiotensin II was studied in the isolated perfused rabbit kidney. Angiotensin II induced a dose-dependent increase in perfusion pressure and urine flow when given through the renal artery. Phenoxybenzamine, when added to the perfusion medium, caused a decrease in perfusion pressure but an increase in urine flow. Further addition of acetyl salicylic acid to the perfusion medium significantly reversed both agonistic effects of angiotensin II. The possible mechanisms of these findings are discussed.