Association analysis of three ABCB1 (MDR1) gene variants (C1236T, G2677A/T and C3435T) and their genotype/haplotype combinations with the familial Mediterranean fever

RÜSTEMOĞLU, AYDIN; GÜMÜŞ AKAY, GÜVEM; KARAKUŞ, NEVİN; YİĞİT, SERBÜLENT; Sahin, Server; TAŞLIYURT, TÜRKER

doi:10.3109/00498254.2014.915071

Association analysis of three ABCB1 (MDR1) gene variants (C1236T, G2677A/T and C3435T) and their genotype/haplotype combinations with the familial Mediterranean fever

RÜSTEMOĞLU A., GÜMÜŞ AKAY G., KARAKUŞ N., YİĞİT S., Sahin S., TAŞLIYURT T.

XENOBIOTICA, cilt.44, sa.10, ss.933-940, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 44 Sayı: 10
Basım Tarihi: 2014
Doi Numarası: 10.3109/00498254.2014.915071
Dergi Adı: XENOBIOTICA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.933-940
Anahtar Kelimeler: ABCB1, FMF, haplotype, polymorphism, Turkey, INFLAMMATORY-BOWEL-DISEASE, MULTIDRUG-RESISTANCE GENE, COLCHICINE RESPONSE, T-POLYMORPHISM, HAPLOTYPE, TRANSPORTER, EXPRESSION, PYRIN, RISK, ALLELE
Ankara Üniversitesi Adresli: Evet

Özet

1. Familial Mediterranean fever (FMF) is considered an autosomal recessive disorder, associated with a single gene named Mediterranean fever (MEFV). The aim of this study was to perform genotyping and haplotyping analysis of the multidrug resistance (ATP-binding cassette, subfamily B, member 1 - ABCB1) gene in FMF patients.