Roles of NMDA receptor antagonists in neuropathic pain NMDA reseptör antagoni̇stleri̇ni̇n nöropati̇k aǧridaki̇ rolleri̇

Atila S., ALAGÖZ Z.

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.39, no.1, pp.51-68, 2010 (Scopus) identifier

  • Publication Type: Article / Review
  • Volume: 39 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1501/eczfak_0000000554
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.51-68
  • Keywords: Glutamat, Ketamine, Neuropathic Pain, NMDA Receptor Antagonists, NR2B-Specific Noncompetitive receptor antagonists
  • Ankara University Affiliated: Yes

Abstract

Neuropathic pain is defined as "pain initiated or caused by a primary lesion or dysfunction in the nervous system". The excitatory amino acids and several kinds of peptides play a major role in nociception. The excitatory amino acid glutamate was shown to play a role in neuropathic pain. Recently, N-methyl-D-aspartate receptors (NMDARs), subtype of glutamate receptors have attracted particular attention because of their involvement in nociceptive modulation. Antagonists of the NMDA receptor have been hypothesized to be effective for the treatment of the neuropathic pain.