Roles of NMDA receptor antagonists in neuropathic pain NMDA reseptör antagoni̇stleri̇ni̇n nöropati̇k aǧridaki̇ rolleri̇

Atila S., ALAGÖZ Z.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.39, sa.1, ss.51-68, 2010 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 39 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1501/eczfak_0000000554
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.51-68
  • Anahtar Kelimeler: Glutamat, Ketamine, Neuropathic Pain, NMDA Receptor Antagonists, NR2B-Specific Noncompetitive receptor antagonists
  • Ankara Üniversitesi Adresli: Evet

Özet

Neuropathic pain is defined as "pain initiated or caused by a primary lesion or dysfunction in the nervous system". The excitatory amino acids and several kinds of peptides play a major role in nociception. The excitatory amino acid glutamate was shown to play a role in neuropathic pain. Recently, N-methyl-D-aspartate receptors (NMDARs), subtype of glutamate receptors have attracted particular attention because of their involvement in nociceptive modulation. Antagonists of the NMDA receptor have been hypothesized to be effective for the treatment of the neuropathic pain.