Pharmaceutical insights into nanoscale drug delivery systems and chromatographic approaches for melanoma treatment

Ghodrati A. D., Gebrehiwot W., Amasya G., Gümüştaş M., Sengel-Turk C. T.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.274, 2026 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 274
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.jpba.2026.117434
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO)
  • Ankara Üniversitesi Adresli: Evet

Özet

Due to its potential for metastasis and resistance to standard treatments, melanoma, a very aggressive type of skin cancer, presents substantial challenges in clinical care. Nanocarrier based approaches have become a viable tactic to overcome these limitations. This review offers a thorough analysis of melanoma, its molecular basis, and innovative therapeutic strategies. It emphasizes the revolutionary potential of nanoparticles in melanoma therapy, leveraging their unique properties for targeted drug delivery and imaging. Several nanoparticle formulations are explored, demonstrating how they can improve treatment efficacy, reduce adverse effects, and overcome drug resistance mechanisms. These formulations include liposomes, polymeric nanoparticles, and inorganic nanoparticles. In addition, chromatographic analyses of these nanoscale systems are reviewed, highlighting their essential role in characterizing drug-nanocarrier interactions, assessing stability, and ensuring quality control in pharmaceutical development. Furthermore, novel tactics including personalized nanomedicine and combination therapies are investigated to maximize treatment results. Despite notable progress, challenges such as nanoparticle stability and translational barriers necessitate further research efforts. Overall, nanoparticlebased therapies offer a promising avenue for advancing melanoma treatment, ushering in a new era of precision medicine and improved patient care.