Interleukin-6 and hepcidin expression changes in cardiac tissue of long-term trained and untrained rats after exhaustive exercise

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Sarikaya B., Dursun A. D., Taylan Deveden E. Y., Pinar L.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.6, pp.1940-1946, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1703-73
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1940-1946
  • Keywords: Hepcidin, interleukin-6, heart, exhaustive exercise, SKELETAL-MUSCLE, IRON, INFLAMMATION, PROTEIN, SERUM, RESISTANCE, CYTOKINES, RESPONSES, ISCHEMIA, MEDIATOR
  • Ankara University Affiliated: Yes

Abstract

Background/aim: Exercise benefits the cardiovascular system, but strenuous exercise can cause cardiac damage and induce cytokine production, particularly that of interleukin-6 (IL-6). Hepcidin, which is primarily regulated by IL-6, increases after exercise. Hepcidin is a possible protective factor against the adverse effects of strenuous exercise such as oxidative stress. The aim of the study is to reveal that training increases hepcidin and attenuates increased levels of IL-6 in the hearts of exhaustively exercised rats by comparing the IL-6 and hepcidin mRNA expression levels in trained and untrained groups.