Acute myocardial infarction, ischemic cerebrovascular disease and variceal bleeding due to portal vein thrombosis in a patient with hereditary thrombophilia

Baran B., YILMAZ Y., ALGIN O., Keskin M., KIYICI M., Kocamaz G., ...More

Blood Coagulation and Fibrinolysis, vol.19, no.3, pp.243-246, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1097/mbc.0b013e3282f30ae5
  • Journal Name: Blood Coagulation and Fibrinolysis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.243-246
  • Keywords: Factor V Leiden mutation, Hereditary thrombophilia, Methylenetetrahydrofolate mutation, Portal vein thrombosis
  • Ankara University Affiliated: No

Abstract

We report on a 43-year-old female patient with multiple thrombotic risk factors who, in a few months, developed acute myocardial infarction, an ischemic cerebrovascular event and variceal bleeding due to portal vein thrombosis. The factor V Leiden mutation was carried in heterozygous form, homocysteine was elevated at 19.6 μmol/l, and methylenetetrahydrofolate reductase C677T mutation was carried in homozygous form. Moderately increased plasma homocysteine level and a reduced protein S activity were evident. Anticardiolipin IgG antibodies were mildly positive. We conclude that the presence of multiple genetic and environmental risk factors greatly amplifies the risk of clinical thrombotic events. © 2008 Lippincott Williams & Wilkins, Inc.