Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide

Shirinzadeh H., SÜZEN S., ALTANLAR N., Westwell A. D.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.15, sa.3, ss.291-297, 2018 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4274/tjps.55707
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.291-297
  • Anahtar Kelimeler: Indole, 1,2,4-triazole, 1,3,4-thiadiazole, MRSA, C. krusei, RESISTANT STAPHYLOCOCCUS-AUREUS, NORA EFFLUX PUMP, ANTIFUNGAL ACTIVITY, CANDIDA-KRUSEI, TRIAZOLE, EPIDEMIOLOGY, MECHANISMS, INHIBITORS, AGENTS
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of biologic activities such as antibacterial and antifungal. In this study antimicrobial activities of some indole derivatives mainly substituted with 1,2,4-triazole, 1,3,4-thiadiazole and hydrazinecarbothioamide were investigated to evaluate their efficacy.