Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide

Shirinzadeh H., SÜZEN S., ALTANLAR N., Westwell A. D.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.15, no.3, pp.291-297, 2018 (ESCI, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.4274/tjps.55707
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.291-297
  • Keywords: Indole, 1,2,4-triazole, 1,3,4-thiadiazole, MRSA, C. krusei, RESISTANT STAPHYLOCOCCUS-AUREUS, NORA EFFLUX PUMP, ANTIFUNGAL ACTIVITY, CANDIDA-KRUSEI, TRIAZOLE, EPIDEMIOLOGY, MECHANISMS, INHIBITORS, AGENTS
  • Ankara University Affiliated: Yes

Abstract

Objectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of biologic activities such as antibacterial and antifungal. In this study antimicrobial activities of some indole derivatives mainly substituted with 1,2,4-triazole, 1,3,4-thiadiazole and hydrazinecarbothioamide were investigated to evaluate their efficacy.