Characterization of the ultrastructure of gingival mast cells in alloxan-induced diabetic rats

Ozsoy N., GÜL N.

CELL BIOCHEMISTRY AND FUNCTION, cilt.23, sa.5, ss.333-337, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1002/cbf.1161
  • Dergi Adı: CELL BIOCHEMISTRY AND FUNCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.333-337
  • Anahtar Kelimeler: diabetes mellitus (alloxan-induced), Wistar albino rat, gingiva, mast cell, ultrastructure, PERIODONTAL-DISEASE, PIECEMEAL DEGRANULATION, MELLITUS, INFECTION
  • Ankara Üniversitesi Adresli: Evet

Özet

The morphological changes of gingival mast cells of alloxan-induced diabetic rats were studied by electron microscopy. The following observations were made. The cell nucleus and cytoplasm degenerated. The electron density of the granules in the cell cytoplasm clearly decreased. Some granules had dense irregular threads and the granules were surrounded by a thin vacuole. A ghost vacuole formed in some mast cells and disorganized materials accumulated in the cytoplasm. The mast cell nuclei were generally irregular and degenerating mast cells had pyknotic nuclei. General destruction of the cell membrane and granule shedding in some samples was noted and mitochondria with atypical cristae in the cytoplasm of the mast cells were seen. We conclude that the characteristics of the ultrastructure of gingival mast cells in diabetics are distinctive and should be used as criteria for pathogenesis of gingival inflammation. Copyright (c) 2004 John Wiley & Sons, Ltd.