Antioxidant evaluations of novel N-H and N-substituted indole esters

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Olgen S., Coban T.

Biological and Pharmaceutical Bulletin, cilt.26, sa.5, ss.736-738, 2003 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 5
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1248/bpb.26.736
  • Dergi Adı: Biological and Pharmaceutical Bulletin
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.736-738
  • Anahtar Kelimeler: anti-oxidant activity, N-substituted indole derivatives, superoxide dismutase, lipid peroxidation, RADICAL SCAVENGING ACTIVITY
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

The anti-lipid peroxidation (LP) activity and anti-superoxide formation (SOD) of new N-H and N-substituted indole derivatives were evaluated to determine their antioxidant activity. The results showed that compounds 1, 2, 5, 9 and 12 demonstrate considerable inhibition of lipid peroxidation of mouse liver homogenate. On the other hand, compounds 5 and 12 showed anti-superoxide formation activity at a concentration of 10-4 M. Consequently, it can be concluded that these compounds exhibit important activity compared with reference compound α-tocopherol (vitamin E).