Antioxidant evaluations of novel N-H and N-substituted indole esters

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Olgen S., Coban T.

Biological and Pharmaceutical Bulletin, vol.26, no.5, pp.736-738, 2003 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 5
  • Publication Date: 2003
  • Doi Number: 10.1248/bpb.26.736
  • Journal Name: Biological and Pharmaceutical Bulletin
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.736-738
  • Keywords: anti-oxidant activity, N-substituted indole derivatives, superoxide dismutase, lipid peroxidation, RADICAL SCAVENGING ACTIVITY
  • Open Archive Collection: AVESIS Open Access Collection
  • Ankara University Affiliated: Yes

Abstract

The anti-lipid peroxidation (LP) activity and anti-superoxide formation (SOD) of new N-H and N-substituted indole derivatives were evaluated to determine their antioxidant activity. The results showed that compounds 1, 2, 5, 9 and 12 demonstrate considerable inhibition of lipid peroxidation of mouse liver homogenate. On the other hand, compounds 5 and 12 showed anti-superoxide formation activity at a concentration of 10-4 M. Consequently, it can be concluded that these compounds exhibit important activity compared with reference compound α-tocopherol (vitamin E).