Akademik Veri Yönetim Sistemi
ANKARA CITY HOSPITAL MEDICAL JOURNAL, cilt.2024, sa.3, ss.112-117, 2024 (TRDizin)
Introductıon: This study aimed to evaluate interleukin (IL)-13 and IL-8 levels in patients with allergic rhinitis who were and were not receiving specific immunotherapy.
Methods: A total of 84 patients being followed up in the immunology-al- lergy outpatient clinic for allergic rhinitis (42 receiving immunotherapy) and 23 healthy control subjects were included. Serum IL-13 and IL-8 le- vels were measured by enzyme-linked immunosorbent assay in all groups. Allergic rhinitis patients were also evaluated in terms of symptom scores, IgE levels, and skin prick test results.
Results: Comparison of serum IL-13 and IL-8 among the groups demonst- rated that levels of both cytokines were significantly higher in both allergic rhinitis patient groups compared to controls (p<0.001), and significantly higher in symptomatic allergic rhinitis patients compared to patients recei- ving immunotherapy (p<0.001 for IL-13, p=0.004 for IL-8).
Conclusion: Immunotherapy is the only curative treatment for allergic rhi- nitis. The results of our study suggest that immunotherapy exerts its effect by modifying levels of IL-13 and IL-8 in addition to previously well-known cytokines.