Effect of specific immunotherapy on plasma interleukin 13 and 8 levels in patients with allergic rhinitis
ANKARA CITY HOSPITAL MEDICAL JOURNAL, cilt.2024, sa.3, ss.112-117, 2024 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2024 Sayı: 3
- Basım Tarihi: 2024
- Doi Numarası: 10.5505/achmedj.2024.03016
- Dergi Adı: ANKARA CITY HOSPITAL MEDICAL JOURNAL
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.112-117
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Üniversitesi Adresli: Evet
Özet
Introductıon: This study aimed to evaluate interleukin (IL)-13 and IL-8 levels in patients with allergic rhinitis who were and were not receiving specific immunotherapy.
Methods: A total of 84 patients being followed up in the immunology-al- lergy outpatient clinic for allergic rhinitis (42 receiving immunotherapy) and 23 healthy control subjects were included. Serum IL-13 and IL-8 le- vels were measured by enzyme-linked immunosorbent assay in all groups. Allergic rhinitis patients were also evaluated in terms of symptom scores, IgE levels, and skin prick test results.
Results: Comparison of serum IL-13 and IL-8 among the groups demonst- rated that levels of both cytokines were significantly higher in both allergic rhinitis patient groups compared to controls (p<0.001), and significantly higher in symptomatic allergic rhinitis patients compared to patients recei- ving immunotherapy (p<0.001 for IL-13, p=0.004 for IL-8).
Conclusion: Immunotherapy is the only curative treatment for allergic rhi- nitis. The results of our study suggest that immunotherapy exerts its effect by modifying levels of IL-13 and IL-8 in addition to previously well-known cytokines.