Akademik Veri Yönetim Sistemi
HUMAN IMMUNOLOGY, cilt.85, sa.4, ss.1-6, 2024 (SCI-Expanded)
Purpose: Case reports of subacute thyroiditis (SAT) following coronavirus disease‐19 (COVID‐19) have been
reported. Because the relationship between SAT and human leucocyte antigen (HLA) alleles is known, we
aimed to determine HLA alleles that may predispose a patient to coronavirus infection and/or post‐COVID‐
19 SAT.
Method: This retrospective study was conducted in 51 patients with SAT and 190 healthy bone marrow donor
volunteers. HLA‐A, −B, −C, −DRB1, and −DQB1 were genotyped using next‐generation sequencing. The
study population was grouped into four groups according to SAT and COVID‐19 history.
Results: The frequency of HLA‐DQB1*04:02 was higher in the COVID‐19(−) participants than in the COVID‐19
(+) participants (=0.045). The presence of HLA‐DQB1*04:02 was associated with a lower risk of developing
COVID‐19 in all groups. The frequencies of HLA‐B*35:01, HLA‐B*35:03, HLA‐DRB1*12:01, and HLA‐
DRB1*14:01 were different in the SAT(+) group than in the SAT(−) group in COVID‐19(−) group. The frequencies of HLA‐C*12:03, HLA‐DQB1*06:04, HLA‐DRB1*13:02, and HLA‐DRB1*13:03 were different in the
SAT(+) group than in the SAT(−) group in the COVID‐19 (+) group.
The difference in the frequency of these HLA types remains significant when the four groups are included
together as follows: In the COVID‐19(+) group, the frequencies of HLA‐DRB1*13:02, and HLA‐DRB1*13:03
were higher in the SAT(+) group than in the SAT(−) group. In the COVID‐19(−) group, the frequencies of
HLA‐B*35:03, HLA‐DRB1*12:01, and HLA‐DRB1*14:01 were higher in the SAT (+) group than in the SAT
(−) group.
Conclusion: HLA alleles associated with SAT susceptibility may vary with COVID‐19 history