Imatinib Mesylate induces apoptosis in chronic myeloid leukemia cells by triggering nitric oxide production

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Karadağ Gürel A., Özkan T., Altınok Güneş B., Sunguroğlu A., Aktan F.

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, cilt.12, ss.667-671, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4328/acam.20379
  • Dergi Adı: ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.667-671
  • Anahtar Kelimeler: Chronic myeloid leukemia, Imatinib mesylate (STI571, Gleevec), Nitric oxide, Capillary electrophoresis, Apoptosis, ABL TYROSINE KINASE, OXIDATIVE STRESS, INHIBITOR
  • Ankara Üniversitesi Adresli: Evet

Özet

Aim: Chronic Myeloid Leukemia (CML) is a myeloproliferative disease characterized by abnormal clonal proliferation of hematopoietic stem cells. The overproduction of nitric oxide (NO) causes reactive oxygen species and subsequent oxidative stress to cell toxicity. The production of factors such as nitric oxide (NO) and reactive oxygen species (ROS) in the cell and/or tissue environment affects the behavior of normal cells and cancer cells. In this study, we aimed to investigate the effects of nitric oxide formed as a result of Imatinib Mesylate (STI571, Gleevec (R)) metabolism on cell death.