Akademik Veri Yönetim Sistemi
Turk Hijyen ve Deneysel Biyoloji Dergisi, cilt.82, sa.2, ss.281-290, 2025 (Scopus)
Objective: Borderline ovarian tumor (BOT), known as ovarian tumor with low malignant potential, constitutes 10-20% of all ovarian malignancies. It is freguently possible to diagnose BOT before surgery, it is often diagnosed by frozen examination during surgery or by histological examination of the ovarian tissue after the operation. In this study, we aimed to retrospectively evaluate the accuracy rate of frozen examination results of BOT in a single center. Methods: All final pathology result diagnoses of patients who received BOT between 01.01.2003 and 01.07.2019 were analyzed. Frozen examination results; they were categorized as benign, BOT, at least BOT. The age of the patients, menopausal status, tumor type, tumor bilaterality, tumor size, tumor stage, preoperative cancer antigen-125 (CA-125) U/ml, preoperative carbohydrate antigen 19-9 (CA 19-9) U/ml levels were recorded. The accuracy rate and effect on risk factors of each frozen section diagnosis were analyzed. As surgical procedures, unilateral salpingo-oophorectomy, total hysterectomy and bilateral salpingo-oophorectomy, peritoneal cytology, multiple peritoneal biopsies, appendectomy, infracolic omentectomy and/or lymph node dissection (sampling/systematic) were performed according to the patient’s age and fertility request. Conservative surgery was preferred for patients who wanted fertility and were in the young age group. Results: The accuracy value of frozen diagnosis of all patients was found to be 93.7%. The accuracy rate of frozen diagnosis results was 98.1% for serous BOT and 83.7% for mucinous BOT. Mucinous histology (p<0.001), preoperative CA 19-9 U/ml level (p=0.002) and bilaterality of the tumor (p<0.001) were found to be risk factors for determining the patients’ frozen examination results and permanent pathology results to be incompatible. In our study, individuals with low CA 19-9 levels were found to be 6.06 times more likely to have an incompatible pathology than those with high CA 19-9 levels. Conclusion: The accurate diagnosis of BOT intraoperative frozen examination is very important in determining the extent of the surgical procedure. In our study, the diagnostic accuracy of frozen examination results is low in patients with bilateral tumors, mucinous histology, and high preoperative CA 19-9 levels.