Akademik Veri Yönetim Sistemi
Journal de Pharmacie de Belgique, cilt.53, sa.3, ss.233, 1998 (SCI-Expanded)
Paracetamol is used as an analgesic and antipyretic drug. It is readily absorbed from gastro-intestinal tract with peak plasma concentrations occuring about 10 to 60 minutes after oral administration. Paracetamol is distributed into most body tissues. The usual adult dose by mouth is 0.5 to 1 g every 4 to 6 hours up to a maximum of 4 g daily. In this study, we used a group of tablet dosage form which include only paracetamol. The weight variation, hardness, friability, disintegration time characteristics, assay and especially in vitro dissolution rate which is an important evaluation parameter for active ingredients release property has been investigated. The dissolution methods (paddle and basket) available in the USP XXIII were investigated changing the parameters which were the dissolution medium (pH 5.8 pH 1.2 ) and rotating rate (50 and 100 rpm). The values of hardness, different of disintegration time and also the release rate of the tablets were examined. The dissolution methods and rotating rate were found to effect the release profiles from each sample which contained the same dose paracetamol. And it was also found that the cumulative release from various tablets were different from each other at the same time. According to these results, the cumulative release from the tablets were evaluated kinetically.