Soluble CD30 Levels in Patients with Rheumatoid Arthritis

SONEL TUR B., ATAMAN Ş., Suldur N., Duzgun N., Atay M. B.

TURKISH JOURNAL OF RHEUMATOLOGY, cilt.24, sa.3, ss.131-135, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2009
  • Dergi Adı: TURKISH JOURNAL OF RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.131-135
  • Anahtar Kelimeler: Rheumatoid arthritis, soluble CD30, disease activity, disability, outcome, PRIMARY SJOGRENS-SYNDROME, T-CELLS, DISEASE-ACTIVITY, JOINT COUNTS, EXPRESSION, CYTOKINES, VALIDATION, PREDICTOR, SYNOVITIS, MOLECULE
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: We aimed to determine serum soluble CD30 (sCD30) levels in patients with rheumatoid arthritis (RA) and to analyze their clinical significance in these patients. Materials and Methods: The study group consisted of 49 patients who fulfilled the 1987 American College of Rheumatology diagnostic criteria for RA, and 20 age-and gender-matched healthy controls. Morning stiffness (minutes), pain (visual analog scale, 0-100 mm VAS), fatigue (5-point scale), patient's and physician's general health assessment (0-100 mm VAS), number of tender and swollen joints (total 28 joints), disease activity (DAS28 score), and physical function capacity (disability) (Turkish version of the health assessment questionnaire, HAQ) were assessed. Presence of extraarticular manifestations was recorded. Radiographic assessment of hands and feet was evaluated according to the modified Sharp method. Routine laboratory tests, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor, immunoglobulins, and complements levels were determined by nephelometry. Serum sCD30 levels of the patients with RA and healthy controls were measured by ELISA.