TrAC - Trends in Analytical Chemistry, cilt.197, 2026 (SCI-Expanded, Scopus)
Multiplex biosensors are distinguished as cutting-edge strategies that offer a more holistic analysis by simultaneous, instantaneous monitoring of multiple biomarkers. The system's strength lies in its ability to support the care of complex pathologies, providing the necessary multi-indicator monitoring required for precise diagnostic assessment and personalized therapeutic optimization. Recent technological developments, including the integration of artificial intelligence, point-of-care, lab-on-a-chip systems, and wearable biosensors, have significantly improved the accessibility and usability of multiplex sensing platforms. Multiplex biosensors will play a critical role in enabling early detection, real-time health tracking, and individualized therapeutic interventions, ultimately yielding superior patient results and reducing the burden on healthcare systems. This review sheds light on new investigations by highlighting technological advances such as multiplexing, sensitivity, miniaturization, and integration for non-invasive, minimally invasive, and invasive platforms. It explores promising multi-analyte biosensors, a comprehensive understanding of the mechanisms, types, and challenges of state-of-the-art multi-analyte biosensors, and current challenges and future research areas.