Correlation of Ochratoxin A Exposure to Urinary Levels of 8-Hydroxydeoxyguanosine and Malondialdehyde in a Turkish Population

ATEŞ İ., ÜLKER Ö., Akdemir C., Karakaya A.

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, cilt.86, sa.3, ss.258-262, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00128-011-0225-z
  • Dergi Adı: BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.258-262
  • Anahtar Kelimeler: Ochratoxin A, Urine, Malondialdehyde, 8-Hydroxydeoxyguanosine, OXIDATIVE DNA-DAMAGE, LIPID-PEROXIDATION, MALONALDEHYDE, CONSUMPTION, PREVENTION, TOXICITY, STRESS, CANCER, MARKER
  • Ankara Üniversitesi Adresli: Evet

Özet

Ochratoxin A is one of the most abundant food- contaminating mycotoxins in the world that is immunosuppressive, genotoxic, teratogenic and carcinogenic. Malondialdehyde is a naturally occurring product of lipid peroxidation that is mutagenic and carcinogenic. 8-Hydroxydeoxyguanosine is produced during the interaction of reactive oxygen species and DNA. In this study, Ochratoxin A, malondialdehyde and 8-Hydroxydeoxyguanosine levels of individuals in the study group were measured and results were correlated with each other. Additionally, the correlation of biomarker levels to smoking habit, alcohol and coffee consumption, age and gender of individuals was investigated. As a result of these assessments, a significant correlation was observed between Ochratoxin A exposures and malondialdehyde and 8-Hydroxydeoxyguanosine levels.