Fine needle aspiration cytology (FNAC) in the diagnosis of canine hepatoid gland tumors- A comparative study with histopathology

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YUMUŞAK N., ÇALIŞKAN M., KUTSAL O.

ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.63, no.3, pp.259-266, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.1501/vetfak_0000002738
  • Journal Name: ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.259-266
  • Keywords: Dog, fine-needle aspiration cytology, hepatoid gland tumor, histopathology, malignancy, PERIANAL GLAND, SUBCUTANEOUS MASSES, MAMMARY-TUMORS, NEOPLASMS, LESIONS, DOGS
  • Ankara University Affiliated: Yes

Abstract

In this study, cytological and histological findings of canine hepatoid gland tumors were evaluated for accuracy of cytologic diagnosis. Thirty two samples from dogs of different breed, sex and age were used in the study. Cytologic speciments were prepared by Fine Needle Aspiration Cytology (FNAC) and stained with May-Grunwald Giemsa (MGG). On the other hand, histopathologic tissue samples were obtained surgically. Samples were fixed in 10% neutral formalin solution and embedded in paraffin by routine procedures and stained with hematoxylin-eosin (H&E). In 84.37% of the samples taken from the 32 dogs included in the study, matching cytological and histopathological diagnoses were made, while 5 of the cases were misdiagnosed. Based on cytological examination, from 27 of the samples taken, 18 (66,7%) were diagnosed as Suspect adenoma, 6 (22,2%) as Suspect carcinoma and 3 (11,1%) as Suspect epithelioma. Based on histopathological examination, of the total 32 cases, 22 (68,7%) were diagnosed as Hepatoid gland adenoma (HGA), 7 (21,9%) as Hepatoid gland carcinoma (HGC) and 3 (9,4%) as Hepatoid gland epithelioma (HGE). These results suggest that the FNAC technique and cytological examination could be of use in the early diagnosis of canine hepatoid gland tumors.