Electrochemical characterization and voltammetric anodic stripping methods for the determination of valsartan

Gurler N., Bayraktepe D., Durmus Z., DİNÇ E.

Revista de Chimie, cilt.64, sa.11, ss.1211-1217, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 11
  • Basım Tarihi: 2013
  • Dergi Adı: Revista de Chimie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1211-1217
  • Anahtar Kelimeler: Valsartan, voltammetry, adsorptive anodic stripping voltammetry, BEHAVIOR
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, electrochemical behaviour of valsartan (VSN), an agent used for the treatment of hypertension and VSN-serum protein binding affecting the activity, distribution, excretion, and toxicity of pharmaceutical agents in the body were investigated on glassy carbon electrode by using voltammetric methods. Furthermore, adsorptive stripping methods were developed for the direct determination of the same agent in pharmaceutical preparations and human urine samples. The results were also compared with those obtained by a standard method based on UV absorption and the discrepancies were found to be insignificant at 95% confidence level.