Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.34, no.4, pp.315-327, 2005 (Scopus)
Tea tree oil (TTO) is the essential oil steam distilled from leaves of the Australian native plant Melaleuca alternifolia (Myrtaceae), and has been used widely as a topical antiseptic in Australia for almost 80 years . Recent investigations have confirmed that tea tree oil exhibits broad spectrum antimicrobial activity which can be principally attributed to its high content of terpinen-4-ol. Recent clinical trials have shown promise. In the last fifteen years tea tree oil, as a naturally occurring agent, has become increasingly more popular for a wide range of pharmaceutical and cosmetic products. In this review; the identity, sources, composition, pharmacological properties of tea tree oil have been summarized. Also, the general toxicology profile of tea tree oil was discussed.