Studies on the activities of drug metabolizing enzymes in lung and kidney microsomes of rat Siçan akci̇ǧeri̇ ve böbreǧi̇ mi̇krozomlarinda i̇laç metaboli̇ze eden enzi̇mleri̇n akti̇vi̇teleri̇ üzeri̇ne çalişmalar

EKE B.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.32, sa.1, ss.1-18, 2003 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 1
  • Basım Tarihi: 2003
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-18
  • Anahtar Kelimeler: Kidney, Lung, Microsomes, Monooxygenases, Rat
  • Ankara Üniversitesi Adresli: Evet

Özet

The optimum conditions (pH, protein amount, subtrate concentration and incubation time) of 7-ethoxyresorufin-O-deethylase(EROD), 7-pentoxyesorufin-O-deethylase(PROD), eryhtromycin-N-demethylase (ERND), coumarin 7-hydroxylase (Coh) and p-nitrophenol (PNP) activities in the lung and kidney of rat were determined in microsomes. In this study, it was found out that, different reaction conditions are required for these enzyme activities in rat lund and kidney microsomes.