A rare case of Amanita vidua poisoning

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Kaya E., Karabulut Keklik E. S., Akata I., Horoz E., Yılmaz İ.

TOXICON, cilt.266, ss.1-5, 2025 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 266
  • Basım Tarihi: 2025
  • Dergi Adı: TOXICON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Environment Index, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1-5
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

The similarities between poisonous and edible mushrooms, combined with the inexperience of foragers, increase

the risk of mushroom poisoning. Amatoxin-containing mushrooms are responsible for most fatal mushroom

poisonings. However, there is limited clinical data regarding the toxin content of certain Amanita species, such as

Amanita vidua, and the severity of poisoning they may cause if consumed. This case report presents the first

documented instance of poisoning from A. vidua in the literature. A 72-year-old woman mistakenly consumed a

toxic A. vidua mushroom, believing it to be the non-toxic Amanita vaginata. Approximately 10 hours later, she

arrived at the emergency room with symptoms including nausea, vomiting, and diarrhea. All laboratory parameters

were normal on the first day. However, the patient subsequently developed refractory circulatory shock

and multiple organ failure, which began on the second day and rapidly worsened over the following days. Liver

function tests peaked at 73 hours post-ingestion, showing aspartate transaminase levels of 2534 IU/L, alanine

transaminase levels exceeding 942 IU/L, and lactate dehydrogenase levels above 3325 U/L. We identified

A. vidua by both macroscopic and microscopic examinations. Additionally, high-performance liquid chromatography

(HPLC) analysis of the consumed A. vidua mushroom detected the presence of toxic alpha- and betaamanitins,

confirming amatoxin poisoning. This study details a case of A. vidua mushroom poisoning that

occurred in Türkiye, ultimately resulting in death despite treatment. This is significant as it represents the first

known case of poisoning worldwide from A. vidua, highlighting its potential lethality when ingested by humans