The role of telomerase activity in predicting early recurrence of epithelial ovarian cancer after first-line chemotherapy: A prospective clinical study

Ozmen B., Duvan C. I., Gumus G., Sonmezer M., Gungor M., Ortac F.

European Journal of Gynaecological Oncology, cilt.30, sa.3, ss.303-308, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 3
  • Basım Tarihi: 2009
  • Dergi Adı: European Journal of Gynaecological Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.303-308
  • Anahtar Kelimeler: Primary epithelial ovarian cancer, First-line chemotherapy, Telomerase activity, Recurrence, TRAP assay, EXPRESSION, CELLS, ASSOCIATION, CARCINOMA, ASSAY, RNA
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose of Investigation: To investigate the value of telomerase activity (TA) in the detection of early recurrence in primary epithelial ovarian cancer (EOC). Method(s): In this study, TA was studied in 30 patients with Stage III EOC and 50 control patients with benign gynecological disease. All enrolled EOC patients had had primary cytoreductive surgery and six cycles of platinum-based first-line chemotherapy previously. Semi-quantative TA measurements were done by TRAP assay in ascites, taken at second-look surgery, of cancer patients and in peritoneal washings, taken during planned surgery, of the control group. Result(s): Early recurrence was diagnosed in ten EOC patients (33.3%). Mean TA was statistically higher in EOC patients than in patients with benign disease. However, the mean TA was insignificantly lower in early recurrent EOC patients than in disease-free EOC patients. Conclusion(s): The value of TA is limited in the detection of early recurrence in primary EOC.