Minimal change nephrotic syndrome with stiff-person syndrome: Is there a link?

Ergun I., AKBOSTANCI M. C., Canbakan B., Kocer B., ENSARİ A., Nergizoglu G., ...Daha Fazla

AMERICAN JOURNAL OF KIDNEY DISEASES, cilt.46, sa.1, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1053/j.ajkd.2005.03.009
  • Dergi Adı: AMERICAN JOURNAL OF KIDNEY DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: minimal change disease, nephrotic syndrome, stiff-man syndrome, stiff-person syndrome, GLUTAMIC-ACID DECARBOXYLASE, DEPENDENT DIABETES-MELLITUS, ANTIBODIES, PATIENT, DISEASE
  • Ankara Üniversitesi Adresli: Evet

Özet

Stiff-person syndrome Is a rare, likely Immune-mediated neurological disorder characterized by painful spasms and progressive symmetric rigidity of the axial and proximal limb muscles. Rigidity of truncal muscles and continuous contraction of the agonist and antagonist muscles caused by Involuntary motor-unit firing at rest are the hallmarks of stiff-person syndrome. Immunosuppressive therapy has Induced remission in patients with stiff-person syndrome. We report a patient with stiff-person syndrome with minimal change nephrotic syndrome (MCNS). The pathophysiologic states of stiff-person syndrome and MCNS are unclear. T-Cell-dependent mechanisms are highly suspected for the pathogenesis of both. The diagnosis of stiff-person syndrome was made on the basis of clinical and laboratory findings, and both MCNS and stiff-person syndrome resolved completely with immunosuppressive therapy. To our knowledge, this is the first case of stiff-person syndrome in association with MCNS in the literature. (c) 2005 by the National Kidney Foundation, Inc.