Synthesis of substituted alpha-N-(2-hydroxyethyl)-aminomethylphosphonic acid monoethylester derivatives

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Atıf İçin Kopyala

NAZIR H., Yilmaz H., Tahir M., Ulku D.

SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, cilt.29, sa.10, ss.1821-1828, 1999 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 29 Sayı: 10
• Basım Tarihi: 1999
• Dergi Adı: SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
• Sayfa Sayıları: ss.1821-1828
• Ankara Üniversitesi Adresli: Evet

Özet

Three novel derivatives of alpha-N-(2-hydroxyethyl)aminomethylphosphonic acid monoethyl ester. R-CH[NH2-(CH2)(2)OH]P(O)(O-)(OC2H5), R being 2-hydroxyphenyl, 2-hydroxy-5-nitrophenyl and 2-hydroxy-1-naphthyl, have been prepared by a one-step reaction of the corresponding Schiff bases and diethyl phosphite in over 70 % yields. The structures of these derivatives have been elucidated on the basis of elemental analyses, IR mass and NMR spectroscopic data. A single crystal X-ray study of the first compound has shown that the molecule has a zwitterion structure with (-NH2-OH)(+) and -P(O)(O-)(OR) groups.