Selective apoptotic behaviour of bovine herpesvirus 1 in an epithelial-like microenvironment

Baskin Y., Yazici Z., Baskin H., ÖZKUL A., Olgun N., Bahar I.

ACTA VETERINARIA HUNGARICA, cilt.53, sa.4, ss.479-491, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1556/avet.53.2005.4.8
  • Dergi Adı: ACTA VETERINARIA HUNGARICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.479-491
  • Anahtar Kelimeler: bovine herpesvirus 1, apoptosis, nitric oxide, HEp-2 cells, PROGRAMMED CELL-DEATH, NITRIC-OXIDE, TYROSINE PHOSPHORYLATION, VIRUS, INFECTION, INDUCTION, BHV-1
  • Ankara Üniversitesi Adresli: Evet

Özet

Apoptosis seems to play an important role in the pathogenic profile of bovine herpesvirus 1 (BHV-1) infection. Nitric oxide (NO) is also important as a signal Molecule. In this study, apoptosis was selectively induced in HEp-2 cells in the early stage [1-3 h postinfection (PI)] of BHV-1 multiplication, and this apoptotic process was realised through the caspase-8, and partially through the caspase-3, pathway. BHV-1 infection inhibited staurosporine- (SS-) induced apoptosis only if the SS was added at 6 h PI. The results of this Study showed that the 'NO-apoptosis' relation was realised through the caspase-8 pathway ('outer membrane receptor' pathway) at a later stage of infection in apoptosis induced by BHV-1 + SS. Our previous report (Yazici et al., 2004) and this Study together showed that BHV-1 might induce and inhibit cell-type-specific pathways of apoptosis.