Akademik Veri Yönetim Sistemi
Turkish Journal of Gastroenterology, cilt.8, sa.1, ss.15-20, 1997 (SCI-Expanded)
The effects of Dipyridamole, on hepatic dysfunction produced by portal inflow occlusion was investigated in an experimental model of male Wistar rats. In the treatment group 5 mg/kg Dipyridamole was administered through the mesenteric vein 15 minutes prior to inflow occlusion. Warm ischemia was achieved by application of Pringle's maneuver for 20 minutes to both control and treatment groups. Reperfusion was established by the removal of clamps after 30 minutes. At the end of the reperfusion period, blood samples were obtained for SGOT, SGPT and LDH5. Livers of the animals were removed for tissue water content and ATP concentrations. Also histopathologic examination of the liver tissue were performed. Tissue ATP level and tissue water content were not significantly different among the two groups (p=0.265), p=0.81). The mean SGOT, SGPT and LDH5 levels were significantly higher in the control group compared to those of the treatment group (p<0.0001 and p<0.0001 respectively). Histopathologic examination showed significant intravascular thrombosis in the control group while in the Dipyridamole group only minimal changes were observed. It is concluded that Dipyridamole pre-treatment prevents the damage caused by transient ischemia to hepatocytes by preventing microvascular thrombosis.