Simultaneous determination of morphine, codeine and 6-monoacetylmorphine in urine by GC/MS method GC/MS metodu ile idrarda ayni anda morfin, kodein ve 6-monoasetilmorfin tayini

DUYDU, YALÇIN

doi:10.1501/eczfak_0000000326

Simultaneous determination of morphine, codeine and 6-monoacetylmorphine in urine by GC/MS method GC/MS metodu ile idrarda ayni anda morfin, kodein ve 6-monoasetilmorfin tayini

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DUYDU Y.

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.27, no.2, pp.101-113, 1998 (Scopus)

Publication Type: Article / Article
Volume: 27 Issue: 2
Publication Date: 1998
Doi Number: 10.1501/eczfak_0000000326
Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.101-113
Keywords: 6-MAM, Codeine, GC/MS, Morphine, Urine
Ankara University Affiliated: Yes

Abstract

In the present study a method was developed for simultaneous determination of morphine, codeine and 6-MAM (6-monoacetylmorphine) in urine. We used SPE (Solid Phase Extraction) method in combination with the BSTFA + 1% TMCS derivatization method. Morphine, codeine and 6-MAM were determined in urine by using GC/MS method. We determined recovery rates over 90% for the opiates mentioned above. This method was also applied for the urine obtained from a morphine addict.