Synthesis and evaluation of novel N - H and N-substituted indole-2- and 3-carboxamide derivatives as antioxidants agents

Olgen S., Kilic Z., Ada A. O., Coban T.

Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.22, sa.4, ss.457-462, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/14756360701228491
  • Dergi Adı: Journal of Enzyme Inhibition and Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.457-462
  • Anahtar Kelimeler: indole carboxamides, oxidative stress, free radicals, SOD, lipid peroxidation, MELATONIN, DISEASE, CANCER, SERIES
  • Ankara Üniversitesi Adresli: Evet

Özet

We have previously reported on the synthesis of novel indole derivatives where some compounds showed significant antioxidant activity. Here, we report the synthesis of novel N-H and N-substituted indole-2- and 3-carboxamide derivatives and investigated their antioxidant role in order to identify structural characteristics responsible for activity. Although all compounds showed a strong inhibitory (95-100%) effect on superoxide anion (SOD) only compounds 4, 5 and 6 showed simliar potency for the inhibition of lipid peroxidation (81-94%) which revealed that compounds 4, 5 and 6 possessed highly potent antioxidant properties. Substitution in the 1-position of the indole ring caused the significant differences between the activity results regarding lipid peroxidation inhibition.