HETEROGENEITY OF THE ENDOTHELIAL-CELL AND ITS ROLE IN ORGAN PREFERENCE OF TUMOR-METASTASIS

MCCARTHY S., KUZU I., GATTER K., BICKNELL R.

TRENDS IN PHARMACOLOGICAL SCIENCES, cilt.12, sa.12, ss.462-467, 1991 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 12 Sayı: 12
  • Basım Tarihi: 1991
  • Doi Numarası: 10.1016/0165-6147(91)90637-8
  • Dergi Adı: TRENDS IN PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.462-467
  • Ankara Üniversitesi Adresli: Hayır

Özet

The vascular endothelium is a remarkably heterogeneous organ. In addition to well-characterized anatomical diversity in situ, specific differences are increasingly being recognized between surface antigens on endothelial cells from different tissues, including absence of the classic endothelial marker factor VIII-related antigen (von Willibrand factor) from many endothelial cells. Microvascular heterogeneity extends to properties of endothelial cells thought to be involved in tumour angiogenesis and metastasis, such as growth factor responsiveness and expression of cell adhesion molecules. These findings are not only of relevance to the unambiguous identification and characterization of cultured endothelial cells, but, as Roy Bicknell and colleagues discuss, may explain the phenomenon of preferential organ tumour metastasis and provide novel opportunities for antitumour therapy.