C6-H Bond Functionalization of Indoles: A New Gate

Taskesenligil Y., SARAÇOĞLU N.

SYNTHESIS-STUTTGART, no.21, pp.3417-3433, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2023
  • Doi Number: 10.1055/a-2050-4897
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex
  • Page Numbers: pp.3417-3433
  • Ankara University Affiliated: No


Indoles are valuable precursors in medicinal, bioorganic, and material chemistry and particularly serve as a platform for diversity. However, the scope of the C6-functionalization of indoles was limited until recently. In this short review, we summarize developments in the C6-functionalization reactions of indoles involving transition-metal-cat-alyzed functionalization and Brunsted and Lewis acid catalyzed process -es. The regioselectivity is controlled by remote-C-H activation and hy-drogen bond formation. 1 Introduction 2 Transition-Metal-Catalyzed Functionalization 3 Acid-Catalyzed Processes 4 Conclusion