Trimetazidine revisited: A comprehensive review of the pharmacological effects and analytical techniques for the determination of trimetazidine

BEŞİKCİ A., Oezkan S. A.

Cardiovascular Therapeutics, cilt.26, sa.2, ss.147-165, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 26 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1111/j.1527-3466.2008.00043.x
  • Dergi Adı: Cardiovascular Therapeutics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.147-165
  • Anahtar Kelimeler: cardiac metabolism, electrochemistry, GC, HPLC, spectrophotometry, trimetazidine, ISCHEMIA-REPERFUSION INJURY, ACUTE MYOCARDIAL-INFARCTION, CORONARY-ARTERY-DISEASE, ANTIISCHEMIC AGENT TRIMETAZIDINE, COENZYME-A THIOLASE, ISOLATED RAT-HEART, CHROMATOGRAPHY-MASS-SPECTROMETRY, PERMEABILITY TRANSITION PORE, STABLE ANGINA-PECTORIS, FATTY-ACID OXIDATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Trimetazidine (TMZ) is an effective and well-tolerated antianginal drug that possesses protective properties against ischemia-induced heart injury. Growing interest in metabolic modulation in recent years urged an up-to-date review of the literature on TMZ. This review consists of two major sections: (1) comprehensive and critical information about the pharmacological effects, mechanism of action, pharmacokinetics, side effects, and current usage of TMZ, and (2) developments in analytical techniques for the determination of the drug in raw material, pharmaceutical dosage forms, and biological samples. © 2008 The Authors.