Effect of eNOS and ET-1 Polymorphisms in Thromboangiitis Obliterans

Adiguzel Y., YILMAZ E., Akar N.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.16, sa.1, ss.103-106, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/1076029609336854
  • Dergi Adı: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.103-106
  • Anahtar Kelimeler: Thromboangiitis obliterans (Buerger disease), eNOS, endothelin-1, PROTHROMBIN GENE 20210, BUERGERS-DISEASE, FACTOR-V, MUTATION, ARG
  • Ankara Üniversitesi Adresli: Evet

Özet

Thromboangiitis obliterans (TAO), or Buerger disease, is a segmental Occlusive inflammatory disorder of the arteries and veins, and etiopathogenesis is still obscure. It is strongly connected to the use of tobacco products, especially smoking. Smoking cessation is obligatory for Success of the medical treatment. In the Current Study, we investigated the prevalence of endothelial nitric oxide synthase (eNOS) 894 G -> T and endothelin-1 (ET-1) 8000 T -> C polymorphisms in association with TAO to reveal any possible involvement in the TAO pathophysiology. The T allele of the eNOS 894 G -> T polymorphism was found to be associated with the prevention of TAO.