Effect of eNOS and ET-1 Polymorphisms in Thromboangiitis Obliterans

Adiguzel Y., YILMAZ E., Akar N.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, vol.16, no.1, pp.103-106, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1177/1076029609336854
  • Journal Name: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.103-106
  • Keywords: Thromboangiitis obliterans (Buerger disease), eNOS, endothelin-1, PROTHROMBIN GENE 20210, BUERGERS-DISEASE, FACTOR-V, MUTATION, ARG
  • Ankara University Affiliated: Yes

Abstract

Thromboangiitis obliterans (TAO), or Buerger disease, is a segmental Occlusive inflammatory disorder of the arteries and veins, and etiopathogenesis is still obscure. It is strongly connected to the use of tobacco products, especially smoking. Smoking cessation is obligatory for Success of the medical treatment. In the Current Study, we investigated the prevalence of endothelial nitric oxide synthase (eNOS) 894 G -> T and endothelin-1 (ET-1) 8000 T -> C polymorphisms in association with TAO to reveal any possible involvement in the TAO pathophysiology. The T allele of the eNOS 894 G -> T polymorphism was found to be associated with the prevention of TAO.