Seminal arginase activity in infertility

ELGÜN ÜLKAR S., Kacmaz M., Sen I., Durak I.

UROLOGICAL RESEARCH, cilt.28, sa.1, ss.20-23, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 1
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1007/s002400050004
  • Dergi Adı: UROLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.20-23
  • Anahtar Kelimeler: arginase, seminal plasma, sperm cell, infertility, NITRIC-OXIDE SYNTHASE, SPERM MOTILITY, LIPID-PEROXIDATION, HUMAN-SPERMATOZOA, L-ARGININE, LOCALIZATION, SUPEROXIDE, PLASMA, GENE
  • Ankara Üniversitesi Adresli: Evet

Özet

Arginase(Arg) activity in seminal plasma and sperm cells from infertile men and healthy fertile donors was measured. There were no statistically meaningful differences in seminal plasma Arg activity between the two groups whereas sperm cells from oligospermic infertile men had a higher Arg activity compared with the controls. Some important correlations were established between sperm count and Arg activity (negative values) and sperm motility and Arg activity (positive values) in both sperm cells and plasma samples from infertile men. Results suggest that the arginine-nitric oxide pathway within sperm cells from oligospermic infertile men is disturbed by enhanced Arg activity. We think that this may play a part in sperm dysfunction and male infertility.