Cisapride in the long-term treatment of chronic gastroparesis: A 2-year open-label study

Kendall B., Kendall E., Soykan I., McCallum R.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.25, sa.4, ss.182-189, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 4
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1177/030006059702500402
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.182-189
  • Anahtar Kelimeler: cisapride, chronic gastroparesis, gastric emptying, gastrointestinal symptoms, IDIOPATHIC GASTROPARESIS, DYSPEPTIC PATIENTS, ORAL CISAPRIDE, SYMPTOMS, MOTILITY
  • Ankara Üniversitesi Adresli: Evet

Özet

The effect of long-term cisapride therapy (20 mg orally three times daily for 2 years) on gastric emptying and gastrointestinal symptoms was investigated in 30 patients with severe gastroparesis (24 idiopathic, 6 diabetic). Symptoms were assessed every 2 months, using an overall symptom score based on six symptoms (anorexia, nausea, vomiting, pain, early satiety and bloating), and a a-year mean overall symptom score was used for analysis. Gastric emptying was measured at 0, 6, 12, 18 and 24 months. Of the 24 patients who completed the study, 10 showed a significant improvement in gastric emptying (P < 0.05) and felt improved on therapy, seven patients showing a > 20% improvement in overall symptom score compared to baseline. Results for 15 patients who underwent at least one follow-up gastric-emptying test showed only a weak correlation between individual symptom score and gastric emptying (r = 0.40). Thus long-term cisapride therapy at the study dose produced longterm symptomatic improvement in 42% of patients with severe gastroparesis, with sustained acceleration of gastric emptying for up to 2 years.