Diaphragm unloading via controlled mechanical ventilation alters the gene expression profile

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DeRuisseau K., Shanely R., Akunuri N., Hamilton M., Van Gammeren D., ZERGEROĞLU A. M., ...Daha Fazla

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, cilt.172, sa.10, ss.1267-1275, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 172 Sayı: 10
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1164/rccm.200503-403oc
  • Dergi Adı: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1267-1275
  • Anahtar Kelimeler: gene expression, microarray, muscle atrophy, respiratory muscle, weaning from mechanical ventilation, RAT SKELETAL-MUSCLE, SOLEUS MUSCLE, OXIDATIVE STRESS, CONTRACTILE PROPERTIES, MESSENGER-RNA, IMMOBILIZATION ATROPHY, LIMB IMMOBILIZATION, PROTEIN-SYNTHESIS, DISUSE ATROPHY, SUPPLEMENTATION
  • Ankara Üniversitesi Adresli: Hayır

Özet

Rationale: Prolonged controlled mechanical ventilation results in diaphragmatic inactivity and promotes oxidative injury, atrophy, and contractile dysfunction in this important inspiratory muscle. However, the impact of controlled mechanical ventilation on global mRNA alterations in the diaphragm remains unknown.