Factors involved in the N-oxidation of isomeric aromatic diazines by microsomal preparations
Drug Metabolism and Drug Interactions, cilt.12, sa.2, ss.117-130, 1995 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 2
- Basım Tarihi: 1995
- Doi Numarası: 10.1515/dmdi.1995.12.2.117
- Dergi Adı: Drug Metabolism and Drug Interactions
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.117-130
- Anahtar Kelimeler: diazines, enzyme concentration, enzyme kinetics, in vitro metabolism, incubation time, Km, Ks, substrate concentration, Vmax
- Ankara Üniversitesi Adresli: Evet
Özet
Factors affecting the metabolism of isomeric aromatic diazines in vitro were studied and the conditions which allow maximal metabolism established. The N-oxidation of isomeric diazines was linear with respect to microsomal concentration up to 0.5 g original liver weight per ml using a rabbit microsomal suspension. N-Oxidation was also linear up to between 20–30 minutes depending on substrate studied. The rate of N-oxide production increased with increase in substrate concentration up to about 10 μmol/incubate, after which the rate declined. By using the data obtained the appropriate kinetic factors, K