Birth of a healthy boy using fresh testicular sperm in a patient with Klinefelter syndrome combined with Kartagener syndrome

Vicdan K., Akarsu C., Vicdan A., Sözen E., Bulu B., Biberolu K., ...Daha Fazla

Fertility and Sterility, cilt.96, sa.3, ss.577-579, 2011 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 96 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.fertnstert.2011.06.011
  • Dergi Adı: Fertility and Sterility
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.577-579
  • Anahtar Kelimeler: ICSI, Kartagener syndrome, Klinefelter syndrome, TESE
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: To report a case of Klinefelter syndrome combined with Kartagener syndrome. Design: Case report. Setting: Private IVF center. Patient(s): A 35-year-old man with Klinefelter syndrome combined with Kartagener syndrome causing primary infertility. Intervention(s): Testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI). Main Outcome Measure(s): Sperm recovery, fertilization, and live birth. Result(s): Ovulation induction of the female partner, recovery of spermatozoa by TESE from the male partner and ICSI of 9 metaphase II oocytes resulted in two fertilized oocytes. The delivery of a healthy boy with normal anatomy and 46,XY karyotype was achieved after the transfer of only one 4-cell grade 1 embryo. Conclusion(s): To our knowledge, this case with nonmosaic Klinefelter syndrome combined with Kartagener's syndrome is unique and demonstrates the revolutionary aspects of assisted reproductive technologies (ART) concerning male factor infertility. Copyright © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.