Determination of active ingredients in the pharmaceutical formulations containing hydrochlorothiazide and its binary mixtures with benazepril hydrochloride, triamterene and cilazapril by ratio spectra derivative spectrophotometry and vierordt's method

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Erk N.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.20, sa.1-2, ss.155-167, 1999 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 20 Sayı: 1-2
• Basım Tarihi: 1999
• Doi Numarası: 10.1016/s0731-7085(99)00009-6
• Dergi Adı: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.155-167
• Anahtar Kelimeler: hydrochlorothiazide, benazepril hydrochloride, triamterene, cilazapril, simultaneous determination, pharmaceutical preparations, ratio spectra derivative spectrophotometry, Vierordt's method, PERFORMANCE LIQUID-CHROMATOGRAPHY, UV SPECTROPHOTOMETRY, ENALAPRIL MALEATE, TABLETS, COMBINATION, AMILORIDE
• Ankara Üniversitesi Adresli: Evet

Özet

Procedures were developed for the simultaneous determination of pharmaceuticals in binary mixtures, containing hydrochlorothiazide-benazepril hydrochloride, hydrochlorothiazide-triamterene and hydrochlorothiazide-cilazapril by ratio spectra derivative spectrophotometry and Vierordt's method. Mean recoveries, relative standard deviations and linearity ranges in calibration graphs of the methods were compared. These procedures were successfully applied to three pharmaceutical formulations for the determination of active ingredients. (C) 1999 Elsevier Science B.V. All rights reserved.