Sensitive detection of levocetirizine as a new generation antihistamine by stripping square wave voltammetry

Ozturk K., Bakirhan N. K., Ozkan S. A., USLU B.

Current Pharmaceutical Analysis, cilt.16, sa.4, ss.424-437, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1573412915666190802165833
  • Dergi Adı: Current Pharmaceutical Analysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
  • Sayfa Sayıları: ss.424-437
  • Anahtar Kelimeler: Levocetirizine, sensor, drug analysis, electrochemistry, solid electrode, tablet, ELECTROCHEMICAL DNA BIOSENSOR, MULTIWALLED CARBON NANOTUBES, BETA-CYCLODEXTRIN POLYMER, FILM-MODIFIED ELECTRODES, AQUEOUS-MEDIA, HUMAN PLASMA, DOSAGE FORM, NANOPARTICLES, HISTAMINE, CETIRIZINE
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2020 Bentham Science Publishers.Background: A new and selective electrochemical sensor was developed for the determination of levocetirizine dihydrochloride, which is an antihistaminic drug. Methods: The investigation was performed by using cyclic, differential pulse and square wave voltam-metric methods on the β-cyclodextrin modified glassy carbon electrode. It is thereby planned to obtain information about levocetirizine determination and its mechanism. Results: The efficiency of experimental parameters including pH, scan rate, and accumulation potential and time on the anodic response of levocetirizine dihydrochloride was studied. By employing the developed method and under optimized conditions, the current showed linear dependence with a concentra-tion in the range between 2 × 10-8 M and 6 × 10-6 M in pH 2.0 Britton Robinson (BR) buffer. Conclusion: The achieved limits of detection and quantification were found as 3.73 × 10-10 M and 1.24 × 10-9 M, respectively. In addition, the possibility of applying the developed sensor for real sample analysis was investigated, so β-cyclodextrin modified glassy carbon electrode was used to determine levocetirizine dihydrochloride in Xyzal® tablet dosage form. Finally, this sensor was successfully applied to the real sample as a selective, simple, reproducible, repeatable electrochemical sensor.